Combination of estrogen and antipsychotics in the treatment of women with chronic schizophrenia: a double-blind, randomized, placebo-controlled clinical trial.

Introduction: Gender differences in schizophrenia include the age of onset, better treatment response, a better outcome, and the peak of the disease in postmenopausal women. Some evidence indicates that these variations are due to estrogen's effect. The intention of this study was to evaluate the effectiveness of estrogen as an adjuvant agent in the treatment of women with chronic schizophrenia.