Tert-butylhydroquinone preserve testicular steroidogenesis and spermatogenesis in cisplatin-intoxicated rats by targeting oxidative stress, inflammation and apoptosis.

Cisplatin (Cis) is an effective chemotherapeutic intervention against many cancer types. However, the oxidative stress-related toxicities associated with cancer cell resistance-induced dose scaling has limited its long-term use. In the present study, we explored the benefits of the antioxidant, tert-butylhydroquinone (tBHQ; 50 mg/kg b.

Pulmonary Responses Following Quercetin Administration in Rats After Intratracheal Instillation of Amiodarone.

Amiodarone, a drug that treats arrhythmias induces pulmonary toxicity through interplay between oxidative stress and inflammation. Quercetin, a flavonoid widely occurring in natural products possesses antioxidant and anti-inflammatory properties. The aim of the present study was to evaluate the effects of quercetin on pulmonary responses in rats after amiodarone intra-tracheal instillation.

Maternal Geophagy of Calabash Chalk on Foetal Cerebral Cortex Histomorphology.

Background: Calabash chalk, a kaolin-base substance is a common geophagic material mostly consumed by pregnant women. This study investigated its effect on the histomorphology of the foetal cerebral cortex.

Methods: Twelve gestating Wistar rats were divided equally into groups 1 and 2.