The Equatoguinean Malaria Vaccine Initiative: From the Launching of a Clinical Research Platform to Malaria Elimination Planning in Central West Africa.

Fifteen years of investment in malaria control on Bioko Island, Equatorial Guinea (EG), dramatically reduced malaria-associated morbidity and mortality, but the impact has plateaued. To progress toward elimination, EG is investing in the development of a malaria vaccine. We assessed the unique public-private partnership that has had such a significant impact on malaria on Bioko Island and now added a major effort on malaria vaccine development.

Advancing Global Health through Development and Clinical Trials Partnerships: A Randomized, Placebo-Controlled, Double-Blind Assessment of Safety, Tolerability, and Immunogenicity of PfSPZ Vaccine for Malaria in Healthy Equatoguinean Men.

Equatorial Guinea (EG) has implemented a successful malaria control program on Bioko Island. A highly effective vaccine would be an ideal complement to this effort and could lead to halting transmission and eliminating malaria. Sanaria PfSPZ Vaccine ( sporozoite Vaccine) is being developed for this purpose.

Impact of military conflict on a civilian receiving hospital in a war zone.

Objective: To study the impact of war on the workload/finances of a community hospital adjacent to the front.

Summary Background Data: Community hospitals located nearby/within military conflict zones treat trauma casualties while providing routine surgical services to the community.

Methods: Observational study conducted in Ziv hospital (1 of 3 designated receiving hospitals during the second Lebanon War (12/7/2006-14/8/2006).

An approach for high sensitivity detection of prostate cancer by analysis of changes in structuredness of the cytoplasmic matrix of lymphocytes specifically induced by PSA-ACT.

Purpose: An alternative procedure for detection of prostate cancer was examined based on the observation that cells reexposed in vitro to antigenic or mitogenic stimulation will change their intracellular structuredness as measured by polarization of fluorescent light emitted by labeled cells (SCM test).

Materials And Methods: Lymphocytes derived from patients bearing a nonmalignant prostate tumor and healthy individuals were exposed to PSA-ACT, PHA, and MUC-1.

Results: Of sixty-five patients with prostate carcinoma (CaP), sixty-two were correctly diagnosed by the test.

Renal scintigraphy in initial evaluation of renal colic.

To determine the role of renal scintigraphy (RS) in patients with suspected acute urinary tract obstruction, a prospective study was performed comparing RS with emergency intravenous excretory urography (IVU) in 36 examinations. Thirty patients were diagnosed as having renal colic: 28 had dilation of the urinary tracts with (89%) or without (11%) visualized stone; 2 patients with stones did not have stasis at the IVU. An abnormal RS was found in 28 patients with abnormal IVU, while it was normal in the 2 nonobstructed patients (sensitivity = 93%).

Renal function and technetium-99m-dimercaptosuccinic acid uptake in single kidneys: the value of in vivo SPECT quantitation.

The ability to evaluate kidney function in each kidney separately by quantitative SPECT was tested in 20 patients with a single kidney and varying degrees of renal disease. Technetium-99m-dimercaptosuccinic acid (99mTc-DMSA) uptake was compared with renal function measured by creatinine clearance and serum creatinine. There was a good correlation for both serum creatinine (r = 0.

Radionuclide assessment of bladder-emptying function in normal male population and in patients before and after prostatectomy.

Radionuclide assessment of the bladder-emptying function was evaluated in 82 normal individuals and in 16 patients before and after prostatectomy. The parameters evaluated were: average flow rate (AFR), peak flow rate (PFR), corrected peak flow rate (CPFR = PFR/[bladder volume] 0.5), ejection fraction (EF) of the bladder, and post-voiding residual urine (RU) volume.

Chronic dehydration stone disease.

A study was made of 819 patients attending a metabolic stone clinic. A firm diagnosis was made in 708 (86%) and in 132 of these (19%) the diagnosis was thought to be chronic dehydration. The records were available for study for 87 males and 11 females in the chronic dehydration group.

Nephrogenic adenoma in a patient with chronic renal failure associated with intravesical treatment with thiotepa.

We describe a patient with chronic renal failure and transitional cell carcinoma, in whom a nephrogenic adenoma of the bladder was diagnosed after a course of intravesical thiotepa treatment.

Giant cell reparative granuloma of the bladder associated with transitional cell carcinoma.

We report a case of benign giant cell tumor of the bladder associated with transitional cell carcinoma. This giant cell granuloma represents a reactive reaction that must be distinguished from the giant cell malignant tumor. The morphological, histochemical and immunohistochemical criteria that can aid in the differential diagnosis are discussed.

Preoperative prediction of results of prostatectomy by a symptom score and radionuclide uroflowmetry.

A review of preoperative and postoperative symptom scores and radionuclide uroflowmetry in patients undergoing prostatectomy for benign prostatic hyperplasia indicates that there may be certain findings that can help to predict postoperative results. A statistically significant difference was obtained comparing the postoperative results of the symptom score and radionuclide uroflowmetry with the results obtained preoperatively. The correlation between the preoperative ejection fraction and the postoperative total symptom score and irritative score showed a good correlation.

Radionuclide measurement of bladder emptying rate. Simultaneous comparison with urinary flow rate obtained by uroflowmetry.

Mean and peak bladder emptying rates were measured by a radionuclide method using a gamma camera and Tc-99m DTPA and were compared with average and maximum urinary flow rates obtained by a uroflowmeter in 24 simultaneous measurements. A good correlation was found between the two methods. Average urinary flow rate correlates better with mean bladder emptying rate (r = 0.

Radionuclide assessment of bladder outlet obstruction: a noninvasive (1-step) method for measurement of voiding time, urinary flow rates and residual urine.

Radionuclide uroflowmetry was performed in 23 patients with bladder outlet obstruction and 29 controls. The parameters evaluated were voiding time, time to peak flow rate, time for 50 per cent emptying, average flow rate, peak flow rate, corrected peak flow rate [peak flow rate/(bladder volume)0.5], ejection fraction of the bladder and post-void residual urine.

Comparison of a radionuclide method and catheterization for the measurement of residual volume of urine in the bladder.

Residual urine volume in the bladder was measured using a gamma camera and Tc-99m DTPA labeling of the urine and was compared to urethral catheterization in 21 male patients. The results of the radionuclide method did not differ significantly from the catheterization (P less than 0.001) and a good correlation was found between the two methods (r = 0.

Inverted papilloma of ureter.

We report a case of an inverted papilloma of the ureter. The clinical presentation, biological behaviour and management of this extremely rare lesion are reviewed. Although behaving benignly, their malignant potential remains to be established.

Vasectomy to prevent acute epididymo-orchitis after prostatic adenomectomy: still a controversy.

There has been a controversy for almost 80 years about the usefulness of vasectomy in the prevention of acute epididymo-orchitis (EO) after prostatic adenomectomy (PA). In the last few years, improved surgical equipment and new more effective antibiotics have drastically diminished the incidence of this complication. The purpose of this report is to show that because of the devastating effect of the disease, and in spite of its low incidence there is still a clear indication for vasectomy, and also that infected urine, a preoperative indwelling urethral catheter, duration of postoperative catheterization and postoperative complications do not affect the incidence of post-PA acute EO.