Antifungal promising agents of zinc(II) and copper(II) derivatives based on azole drug.

A series of new metal complexes, [Zn(KTZ)(Ac)]·HO (1) [Zn(KTZ)Cl]·0.4CHOH (2), [Zn(KTZ)(HO)(NO)](NO) (3), [Cu(KTZ)(Ac)]·HO (4) [Cu(KTZ)Cl]·3.2HO (5), [Cu(KTZ)(HO)(NO)](NO)·HO (6), were synthesized by a reaction of ketoconazole (KTZ) with their respective zinc or copper salts under mild conditions.