Publications by authors named "Emanuella Feitosa Carvalho"
Article Synopsis
- This study investigated how β-methylphenylethylamine (β-MPEA) and octopamine affect the contractions of the gastrointestinal tract in rats, focusing on their interaction with specific receptors.
- β-MPEA caused contractions in certain conditions and relaxed previously contracted tissues, while octopamine consistently induced relaxation and slowed gastrointestinal transit in awake rats.
- The findings suggest that β-MPEA's excitatory effects may involve serotonin receptors, whereas octopamine seems to inhibit gut contractility through both serotonin and trace amine receptors.
Neryl butyrate induces contractile effects on isolated preparations of rat aorta.
Naunyn Schmiedebergs Arch Pharmacol
January 2020
Neryl butyrate is a constituent of volatile oils obtained from aromatic plants. Aliphatic organic compound analogues chemically close to neryl butyrate possess vasodilator properties in rat aorta. To evaluate whether neryl butyrate has relaxing properties, this study tested its effects on isolated rat aorta.
View Article and Find Full Text PDFA group of nitro compounds contains a benzene ring in a short aliphatic chain with the NO group, property that supposedly favors its vasodilator profile. In this study, we evaluated in isolated rat aorta the effects of 1-nitro-2-propylbenzene (NPB), a nitro compound containing the NO in the aromatic ring. In aorta precontracted with KCl, NPB (1-3000 μm) induced full endothelium-independent relaxation.
View Article and Find Full Text PDFβ-Phenylethylamine (β-PEA) is a trace amine with chemical proximity to biogenic amines and amphetamines. It is an endogenous agonist of trace amine-associated receptors (TAARs) that acts as a neuromodulator of classic neurotransmitters in the central nervous system. At high concentrations, β-PEA contracts smooth muscle, and a role for TAARs in these responses has been postulated.
View Article and Find Full Text PDFWhat is the central question of this study? Acute acidosis that results from short-term exercise is involved in delayed gastric emptying in rats and the lower responsiveness of gastric fundus strips to carbachol. Does extracellular acidosis decrease responsiveness to carbachol in tissues of sedentary rats? How? What is the main finding and its importance? Extracellular acidosis inhibits cholinergic signalling in the rat gastric fundus by selectively influencing the G protein signalling pathway. Acute acidosis that results from short-term exercise delays gastric emptying in rats and decreases the responsiveness to carbachol in gastric fundus strips.
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