Publications by authors named "Emanuele Favaron"

Article Synopsis
  • - The study investigates the efficacy of CO laser therapy for treating vaginal atrophy due to genitourinary syndrome of menopause (GSM) using an animal model of 25 ewes, where 20 underwent ovariectomy to simulate menopause.
  • - Monthly treatments of CO laser and vaginal estrogen were compared, with estrogen showing significant improvements in capillary loops and epithelial thickness, while CO laser therapy did not show any changes in microcirculatory parameters.
  • - The research suggests that different treatment parameters may be needed for effective application in humans, given the anatomical differences, particularly the thinner vaginal epithelium in ewes compared to that in humans.
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Background: The sublingual microcirculation presumably exhibits disease-specific changes in function and morphology. Algorithm-based quantification of functional microcirculatory hemodynamic variables in handheld vital microscopy (HVM) has recently allowed identification of hemodynamic alterations in the microcirculation associated with COVID-19. In the present study we hypothesized that supervised deep machine learning could be used to identify previously unknown microcirculatory alterations, and combination with algorithmically quantified functional variables increases the model's performance to differentiate critically ill COVID-19 patients from healthy volunteers.

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Objectives: In this study, we hypothesized that coronavirus disease 2019 patients exhibit sublingual microcirculatory alterations caused by inflammation, coagulopathy, and hypoxemia.

Design: Multicenter case-controlled study.

Setting: Two ICUs in The Netherlands and one in Switzerland.

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