Publications by authors named "Emanuela Gaggiano"
Objectives: To develop an intensive training programme for ultrasound (US)-guided synovial tissue (ST) biopsy on knees and wrists in inflammatory arthritis and to assess the learning curve, patient tolerability, sample quality and trainees' expectations.
Methods: Active or remission rheumatoid arthritis patients were enrolled. Nine trainees joined the 4-month programme in a centre experienced in performing US-guided ST biopsies consisting of four sequential phases: (1) observation, (2) performance of guided step-by-step phases, (3) execution of the whole procedure on paired joints (knees or wrists) of the same patient in parallel with the trainer and (4) performance of the procedure autonomously.
Objectives: We aimed to evaluate the drug retention rate (DRR) of secukinumab, an anti-IL-17A monoclonal antibody, in patients with psoriatic arthritis (PsA) in a real-life cohort, and to assess the impact of comorbidities and patient clinical characteristics on the DRR of secukinumab.
Methods: A retrospective study of prospective followed-up patients was performed to evaluate the DRR of secukinumab on patients with PsA attending the recruiting centres between January 2016 and June 2022.
Results: In 207 patients with PsA, a 60-month DRR of secukinumab of 57.
Patients with chronic Inflammatory Arthritis (IA), such as Rheumatoid Arthritis (RA) and Spondyloarthritis (SpA) are more likely to experience psychosocial impairment. Gastrointestinal (GI) symptoms are also present, especially in Spondyloarthritis. No data are available on the relationship between gut and brain manifestations and their impact on daily activities in this setting; thus, this study aimed to assess these symptoms in an IA population and identify potential associations.
View Article and Find Full Text PDFBackground: Although mood disorders have been well characterized in Immune-mediated inflammatory diseases, physical function and satisfaction in social roles have not yet been defined as independent domains.
Objective: The study aims to assess satisfaction in social roles and physical function alterations in an Immune-mediated inflammatory diseases population and identify associated characteristics.
Methods: Physical function and social roles satisfaction were evaluated through the Patient-Reported Outcomes Measurement System.
Article Synopsis
- Fatigue is a significant symptom in patients with chronic diseases, especially in those with immune-mediated inflammatory diseases (IMIDs) like inflammatory bowel disease (IBD) and inflammatory arthritis (IA), but the exact causes of this fatigue are not fully understood.
- A study involving 471 participants (137 with IBD, 103 with IA, and 206 controls) found that IBD and IA patients reported significantly more fatigue compared to healthy controls, with factors such as anxiety and depression strongly linked to higher fatigue levels.
- The study suggests that along with the biological aspects, mental health conditions like anxiety and depression play major roles in the fatigue experienced by IMIDs patients, indicating the need for a comprehensive treatment approach that
Background/aim: The identification of novel prognostic biomarkers for melanoma metastasis is essential to improve patient outcomes. To this aim, we characterized miRNA expression profiles in relation to metastasis in melanoma and correlated miRNAs expression with clinical-pathological factors.
Materials And Methods: MiR-145-5p, miR-150-5p, miR-182-5p, miR-203-3p, miR-205-5p and miR-211-5p expression levels were analyzed in primary cutaneous melanomas, including thin and thick melanomas, and in melanoma metastases by quantitative Real-Time PCR.