Publications by authors named "Emanuel Husu"
In a patient with a history of lumbar spine surgery, the management of refractory low back pain may prove challenging. Advancing neuromodulatory techniques and technologies offer the promise of significant and sustained relief in these patients, though prior literature is limited. We present a case of peripheral nerve stimulation at the lumbar medial branches in a woman with chronic axial low back pain following a three-level laminectomy.
View Article and Find Full Text PDFOlder and Better: A Narrative Review of Successful Aging and Adaptation to Pain in Late Life.
Pain Physician
September 2024
Article Synopsis
- A physician's survey of his 80-year-old classmates revealed that their self-reported quality of life (QoL) was unexpectedly high despite various diseases and disabilities, highlighting a potential gap between patient perception and medical assumption.
- Chronic pain significantly affects 60%-75% of older adults, with many experiencing inadequate treatment, and the prevalence increases with age, especially among women.
- The review explores literature on coping strategies for the elderly dealing with chronic pain, emphasizing that adaptive coping is achievable and that healthy aging is possible even in the context of pain.
Key Clinical Message: Medication-induced mood disorders following epidural steroid injections are possible therefore should be disclosed to the patient.
Abstract: Medication-induced mood disorders have been rarely reported following epidural steroid injections (ESI). This case series presents three patients who met the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for substance/medication-induced mood disorder after an ESI.
Background: Exogenous systemic steroid exposure is a well-established risk factor for spinal epidural lipomatosis (SEL), however the association between lumbosacral epidural steroid injections (LESIs) and lumbosacral epidural lipomatosis (LEL) is generally regarded as poorly understood. Our objective was to investigate the rationale and the evidence implicating LESI(s) as a potential cause of LEL as well as the evidence related to use of LESI(s) as a potential pain relieving treatment option for radicular pain in the setting of LEL.
Methods: PubMed, Embase, Google Scholar, OVID were searched from inception until April 2021.
We have previously shown clinical activity of a mammalian target of rapamycin (mTOR) complex 1 inhibitor in Waldenstrom macroglobulinemia (WM). However, 50% of patients did not respond to therapy. We therefore examined mechanisms of activation of the phosphoinositide 3-kinase (PI3K)/Akt/mTOR in WM, and mechanisms of overcoming resistance to therapy.
View Article and Find Full Text PDFArticle Synopsis
- Recent advancements in treating Waldenström's macroglobulinemia (WM) focus on novel therapeutic agents.
- Key therapeutic targets include the PI3K/Akt/mTOR pathway, PKC pathways, NF-kB signaling, tyrosine kinases, and histone deacetylase inhibitors.
- The review highlights the clinical development of these agents and their potential to improve WM treatment.