Increased extracellular ubiquitin in surgical wound fluid provides a chemotactic signal for myeloid dendritic cells.

Purpose: Myeloid dendritic cells (MDC) decline significantly after multiple traumas which might be due to an increased migration into injured regions. Ubiquitin is released from dying cells and is increased in serum after trauma. Ubiquitin can bind to the chemokine receptor CXCR4.

Topogram-based automated selection of the tube potential and current in thoraco-abdominal trauma CT - a comparison to fixed kV with mAs modulation alone.

Objective: To investigate the impact of automated attenuation-based tube potential selection on image quality and exposure parameters in polytrauma patients undergoing contrast-enhanced thoraco-abdominal CT.

Methods: One hundred patients were examined on a 16-slice device at 120 kV with 190 ref.mAs and automated mA modulation only.

Predictors of pulmonary failure following severe trauma: a trauma registry-based analysis.

Background: The incidence of pulmonary failure in trauma patients is considered to be influenced by several factors such as liver injury. We intended to assess the association of various potential predictors of pulmonary failure following thoracic trauma and liver injury.

Methods: Records of 12,585 trauma patients documented in the TraumaRegister DGU® of the German Trauma Society were analyzed regarding the potential impact of concomitant liver injury on the incidence of pulmonary failure using uni- and multivariate analyses.

Subsequent gene expression pattern in dendritic cells following multiple trauma.

Purpose: Major trauma initiates a systemic inflammatory response, which is characterized by systemic release of various chemokines. There is growing evidence for the extraordinary role of dendritic cells (DC) as professional antigen-presenting cells and activators of the immune response. Recently, the impact of severe trauma on DC transcriptomic activation was demonstrated.

The role of TNXB single-nucleotide polymorphisms in recurrent shoulder dislocation.

Tenascin-X (TNX) is an extra-cellular matrix glycoprotein associated with collagen fibril deposition. Recent reports have linked truncated TNX mutations (TNXB) to generalized joint hypermobility and most importantly recurrent joint dislocation. In the present study, we investigated whether there is an association between joint dislocation recurrence rate and the frequency of TNXB single-nucleotide polymorphisms (SNPs).

Clara cell protein 16: A biomarker for detecting secondary respiratory complications in patients with multiple injuries.

Background: Clara cell protein 16 (CC16) has recently gained acceptance as a blood biomarker for detecting direct and indirect lung injury. Although the early elevation of CC16 serum levels has been shown to correlate with pulmonary damage in patients with multiple injuries, the subsequent time course of CC16 serum levels has not been investigated in these patients.

Methods: Fifty-eight patients with multiple injuries, 32 with severe thoracic injury, and 12 healthy volunteers were enrolled in this study.

Circulating leukotriene B4 identifies respiratory complications after trauma.

Background: Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS). Therefore, LTB4-levels were investigated to determine whether they might be a useful clinical marker in predicting pulmonary complications (PC) in multiply traumatized patients.

Methods: Plasma levels of LTB4 were determined in 100 patients on admission (ED) and for five consecutive days (daily).

Soluble triggering receptor on myeloid cells-1 is expressed in the course of non-infectious inflammation after traumatic lung contusion: a prospective cohort study.

Introduction: The triggering receptor expressed on myeloid cells-1 (TREM-1) is known to be expressed during bacterial infections. We investigated whether TREM-1 is also expressed in non-infectious inflammation following traumatic lung contusion.

Methods: In a study population of 45 adult patients with multiple trauma and lung contusion, we obtained bronchoalveolar lavage (BAL) (blind suctioning of 20 ml NaCl (0.

Outcome after operative treatment of Vancouver type B1 and C periprosthetic femoral fractures: open reduction and internal fixation versus revision arthroplasty.

Introduction: The rate of periprosthetic femoral fractures after hip arthroplasty is rising and the estimated current lifetime incidence is 0.4-2.1%.

Lung Organ Failure Score (LOFS): probability of severe pulmonary organ failure after multiple injuries including chest trauma.

Background: Pulmonary complications are common in multiple trauma patients with chest injury. Factors predisposing these critically ill patients to respiratory organ failure are not fully understood.

Methods: Univariate and multivariate logistic regression analyses were used to assess the prognostic value of clinical and laboratory variables (2002-2008; n = 30,616) from the Trauma Registry of the German Trauma Society (DGU).

Functional outcome and complications following PHILOS plate fixation in proximal humeral fractures.

Objectives: Proximal humeral fractures account for approximately 5% of all fractures. New plating techniques have been developed to improve stability. The purpose of this study was to evaluate functional outcome following plate fixation with the Proximal Humeral Internal Locking System (PHILOS) and to analyze potential implant-related complications.

Role of lung contusions on posttraumatic inflammatory response and organ dysfunction in traumatized patients.

Background: Multiple trauma is often accompanied by lung contusion leading to secondary pulmonary inflammation and organ dysfunction. The particular role of lung contusions on the systemic inflammatory response remains unclear. Therefore, the aim of the present study was to compare the degree of lung contusion with markers of inflammation and multiple organ failure (MOF) in trauma patients.

Platelet factor 4 is highly upregulated in dendritic cells after severe trauma.

Dendritic cells (DCs) represent an important linkage between the innate and adaptive immune system and express proinflammatory transcriptomic products early after trauma. The use of a genomic approach recently revealed that platelet factor 4 (PF4) is significantly upregulated in DCs in patients after multiple trauma. However, knowledge about subsequent PF4 alteration and its potential clinical relevance in the context of multiple trauma is still limited.

Apoptosis differs in dendritic cell subsets early after severe trauma.

Dendritic cells (DC) represent an integral part of the immune system. However it is unclear how apoptosis in myeloid DC (MDC) and plasmacytoid DC (PDC) is affected and whether pro- or antiapoptotic properties dominate during the early post-traumatic phase. Blood samples were obtained on day 1 and day 4 after hospital admission from 10 severely traumatized patients and 10 healthy volunteers.

Functional variants of the human 5-lipoxygenase gene and their genetic diagnosis.

Variants in the 5-lipoxygenase (ALOX5) gene are first-line candidate causes for interindividual differences in diseases where leukotrienes play a key role, e.g., inflammatory and immune diseases, atherosclerosis, asthma or the acute respiratory distress syndrome (ARDS).

Periprosthetic humeral fractures after shoulder arthroplasty: operative management and functional outcome.

Background: Currently, little information is available on functional outcome of periprosthetic humeral fractures after shoulder arthroplasty. This investigation aimed to evaluate functional and radiological outcome and patients' satisfaction following this type of injury treated by open reduction and internal fixation.

Methods: Retrospective chart analysis of patients treated at two level-I trauma centers.

Influence of surgical experience on accuracy of acetabular cup positioning in total hip arthroplasty.

Acetabular cup positioning with respect to inclination and anteversion is important in total hip arthroplasty. Positioning affects wear, range of motion, dislocation, and aseptic loosening and is essential for the prognosis after surgery. In this study, we sought to determine the accuracy of surgeons' cup positioning and to test for any differences in accuracy among surgeons with different levels of surgical experience.

Midterm results after operatively stabilised shoulder dislocations in elderly patients.

Anterior shoulder dislocation is frequently seen in young patients. The therapeutic regime in elderly patients after shoulder dislocation is less clearly defined. The aim of this study was to compare the clinical benefit of operative stabilisation following anterior shoulder dislocation in young versus elderly patients.

Adjustment of pelvispinal parameters preserves the constant gravity line position.

There is a high variance in sagittal morphology and complaints between different subjects suffering from spinal disorders. Sagittal spinal alignment and clinical presentation are not closely related. Different parameters have been used to describe the pelvispinal morphology based on standing lateral radiographs.

Frontolimbic brain abnormalities in patients with borderline personality disorder: a volumetric magnetic resonance imaging study.

Background: Dual frontolimbic brain pathology has been suggested as a possible correlate of impulsivity and aggressive behavior. One previous study reported volume loss of the hippocampus and the amygdala in patients with borderline personality disorder. We measured limbic and prefrontal brain volumes to test the hypothesis that frontolimbic brain pathology might be associated with borderline personality disorder.