Publications by authors named "Emanuel F Lopes"
Article Synopsis
- * GABA acts on DA axons through GABA receptors, affecting both the strength of DA release and its short-term plasticity, with specific sources of GABA contributing to this modulation identified.
- * The interaction between GABA and DA signaling might play a key role in psychomotor disorders like Parkinson's disease, suggesting potential new drug targets to regulate DA output.
Article Synopsis
- Striatal dopamine (DA) is essential for regulating action and learning, with recent findings indicating that its release is inhibited by GABA in the striatum.
- The role of plasma membrane GABA uptake transporters (GATs), particularly GAT-1 and GAT-3 located on astrocytes and neurons, in influencing DA output has emerged as a key focus of the research.
- In a mouse model of early parkinsonism, reduced GAT levels lead to increased inhibition of DA release and highlight maladaptive changes affecting DA output in critical regions of the striatum.
The cystic fibrosis transmembrane conductance regulator (CFTR) channel is an ion channel responsible for chloride transport in epithelia and it belongs to the class of ABC transporters. The deletion of phenylalanine 508 (F508del) in CFTR is the most common mutation responsible for cystic fibrosis. Little is known about the effect of the mutation in the isolated nucleotide binding domains (NBDs), on dimer dynamics, ATP hydrolysis and even on nucleotide binding.
View Article and Find Full Text PDFArticle Synopsis
- Nigrostriatal dopamine (DA) plays an essential role in action selection and learning, and its release is influenced by various striatal neurotransmitters, primarily GABA and cholinergic interneurons (ChIs).
- Research indicates that GABA can directly inhibit DA release in the striatum through GABA receptors, independent of ChI activity, as demonstrated through experiments with male mice striatal slices.
- Findings suggest that GABA and its receptors provide tonic inhibition of DA release, indicating a significant regulatory role for striatal GABA in dopamine signaling.