Study of purine derivatives and their relation to renal disorders in patients with psoriasis.

Background: Psoriasis (Pso) is a chronic proliferative skin condition associated with hyperuricemia that may impair renal function.

Objectives: The current study investigates the correlation between purine derivatives (PDs) and renal function in patients with Pso.

Patients/methods: This case-control study comprises 30 psoriatic patients and 30 age- and sex-matched healthy controls.

High dose dexamethasone as an alternative rescue therapy for active bleeding in children with chronic ITP: clinical and immunological effects.

High-dose dexamethasone (HD-DXM) is debated as a second-line therapy for chronic Immune thrombocytopenia (ITP) in children. The aim of this study is to evaluate the efficacy and safety of HD-DXM as an emergency therapy in uncontrolled bleeding in children with chronic ITP and to assess its immunological effect on dendritic cells (DCs) percentage and their co-stimulatory markers CD86 and CD83. Totally, 20 children previously diagnosed as chronic ITP were enrolled in this study and all admitted to hospital with uncontrolled bleeding.