Anticancer Effects of New Ceramides Isolated from the Red Sea Red Algae in a Model of Ehrlich Ascites Carcinoma: LC-HRMS Analysis Profile and Molecular Modeling.

Different classes of phytochemicals were previously isolated from the Red Sea algae   as sterols, ketosteroids, fatty acids, and terpenoids. Herein, we report the isolation of three fatty acids-docosanoic acid , hexadecenoic acid , and alpha hydroxy octadecanoic acid -as well as three ceramides- (), (), and ()-with 9-methyl-sphinga-4,8-dienes and phytosphingosine bases. Additionally, different phytochemicals were determined using the liquid chromatography coupled with electrospray ionization high-resolution mass spectrometry (LC-ESI-HRMS) technique.

Chemical Composition of the Red Sea Green Algae : Isolation and In Silico Studies of New Anti-COVID-19 Ceramides.

Coronavirus disease 2019 (COVID-19) is the disease caused by the virus SARS-CoV-2 responsible for the ongoing pandemic which has claimed the lives of millions of people. This has prompted the scientific research community to act to find treatments against the SARS-CoV-2 virus that include safe antiviral medicinal compounds. The edible green algae  .

VEGFR-Mediated Cytotoxic Activity of Isolated Metabolites: A Biological Evaluation and In Silico Study.

Natural products play a remarkable role not only in the synthesis, design, and discovery of new drugs but also as the most prominent source of drugs and bioactive substances. Adding to the search for new sources of safe innovative antitumor drugs, here we reported a phytochemical study on   which revealed promising antiangiogenic agents. Six compounds were isolated and identified as xanthoxyline (), stigmasterol (), oleanolic acid (), salvigenin () rhamnetin () and dihydroquercetin-4'-methyl ether () using nuclear magnetic resonance (NMR) spectroscopic techniques.

Chemical profiling, cytotoxic activities through apoptosis induction in MCF-7 cells and molecular docking of bark nonpolar extract.

The chemical constituents of the nonpolar fractions of the bamboo shoot skin were extensively studied. The phytochemical study was divided into two parts: the first deals with isolation of the chemical constituents using different chromatographic techniques that resulted in isolation of four compounds. The chemical structures of the pure isolated compounds were elucidated using different spectroscopic data.

Chemical Constituent Profiling of var. Pubescens with Selective Cytotoxic Polar Fraction through EGFR Inhibition in HepG2 Cells.

Different extracts of the Bamboo shoot skin var. pubescens were screened against panel of cancer cell lines and normal one. The cell viability results exhibited that the ethyl acetate extract showed the least vitality percentage of 2.

New Antiproliferative Triflavanone from -Isolation, Structure Elucidation and Molecular Docking Studies.

In this study isolates from , a wild plant from the Sinai Peninsula of Egypt, were identified and their selective cytotoxicity levels were evaluated. Phytochemical examination of the ethyl acetate (EtOAc) fraction of the methanolic (MeOH) extract of the plant led to the isolation of a new triflavanone compound (), in addition to the isolation of nine previously reported compounds. These included five dicoumarinyl ethers found in : daphnoretin methyl ether (), rutamontine (), neodaphnoretin (), acetyldaphnoretin (), and edgeworthin (); two flavonoids: genkwanin () and -tiliroside (); -hydroxy benzoic acid () and sitosterol glucoside ().

Cytotoxic, Apoptosis-Inducing Activities, and Molecular Docking of a New Sterol from Bamboo Shoot Skin var. pubescens.

Phytochemical screening of nonpolar fractions from the methanol extract of the Bamboo shoot skin var. pubescens resulted in the isolation of a new sterol-glucoside-fatty acid derivative (6'--octadeca-8'',11''-dienoyl)-sitosterol-3---d-glucoside (), together with six known compounds. The chemical structures of the pure isolated compounds were deduced based on different spectral data.

Anti-inflammatory effect of methoxyflavonoids from ( growing in Egypt.

is a medicinal plant that grows in Sinai Peninsula in Egypt. Phytochemical investigation of methanolic extract led to the isolation of five methoxy flavonoids; Chrysosplenol-D 5,7,4'-trihydroxy- 3,3'-dimethoxy flavone , 5,7-dihydroxy -3,3',4'-trimethoxyflavone , Bonanzin , 3,5,6,7,4'-pentamethoxy flavone a sesquiterpene, Cryptomeridiol and stigmast-5,22-dien-3-O-β-D-glucopyranoside . The anti-inflammatory activity of compounds and was assessed on CaCo2 cells stimulated by lipopolysaccharide (LPS).

Thalassosterol, a New Cytotoxic Aromatase Inhibitor Ergosterol Derivative from the Red Sea Seagrass .

(Forssk.) Den Hartog is a seagrass belonging to the plant family Cymodoceaceae with ubiquitous phytoconstituents and important pharmacological potential, including antioxidant, antiviral, and cytotoxic activities. In this work, a new ergosterol derivative named thalassosterol () was isolated from the methanolic extract of growing in the Red Sea, along with two known first-reported sterols, namely ergosterol () and stigmasterol (), using different chromatographic techniques.

New Cytotoxic Natural Products from the Red Sea Sponge .

Bioactivity-guided isolation supported by LC-HRESIMS metabolic profiling led to the isolation of two new compounds, a ceramide, stylissamide A (), and a cerebroside, stylissoside A (), from the methanol extract of the Red Sea sponge . Structure elucidation was achieved using spectroscopic techniques, including 1D and 2D NMR and HRMS. The bioactive extract's metabolomic profiling showed the existence of various secondary metabolites, mainly oleanane-type saponins, phenolic diterpenes, and lupane triterpenes.

Isolates From Inhibit Progression Of Hepatocellular Carcinoma And .

Herein, we investigated effect of Thymelaea hirsuta isolates on hepatocellular carcinoma. Methanolic extract of led to isolation of two new compounds [6` hydroxyDaphnoretin (9) and Mithnin (15)], seven compounds reported for the first time from genus Thymelaea [Dotriacontanol (1), and 3-ketopentatriacontanoic (2), Docosylcoumarate (5), Docosylcaffeate (6), Daphnodorin B (11), 3`` -epi-dihydrodaphnodorin B (12) and Wikstaiwanone B (14)], and six known compounds. Eight compounds (5, 6, 9, 10, 11, 12, 14, and 15) showed significant anti-proliferative activity on HepG2 cells.

Selective kappa opioid antagonists for treatment of addiction, are we there yet?

Kappa opioid receptor (KOP) is a G-protein coupled receptor mainly expressed in the cerebral cortex and hypothalamus. It is implicated in nociception, diuresis, emotion, cognition, and immune system functions. KOP agonists possess a strong analgesic effect accompanied by a feeling of dysphoria.

IN VITRO ANTI-PROTOZOAL ACTIVITY OF PROPOLIS EXTRACT AND CYSTEINE PROTEASES INHIBITOR (PHENYL VINYL SULFONE) ON BLASTOCYSTIS SPECIES.

Blastocystis is one of the commonest enteric protozoan parasites worldwide. Despite its controversial clinical significance, frequent association with symptoms has necessitated treatment of cases with persistent symptoms. For long time, metronidzole (MTZ) was considered as a basic drug for blastocystosis treatment, however reports of treatment failure as well as its well-known side effects has promoted the search for more safe and effective alternatives.