Simultaneous determination of domperidone maleate and cinnarizine in a binary mixture using derivative ratio spectrophotometry and classical least squares calibration.

This work is concerned with the simultaneous determination of domperidone maleate (DOM) and cinnarizine (CINN) in a binary mixture form without previous separation by two different methods. The first method is the application of derivative ratio spectrophotometry where the linearity range was 2.5-30 micro g/ml, 2.