Efficacy and Safety of Topical Methotrexate Gel 1% in Combination with Microneedling versus Cryotherapy for the Treatment of Cutaneous Warts: A Prospective Randomized Controlled Trial.

Background: Cutaneous warts continue to represent a therapeutic challenge due to treatment resistance and inconvenience of most modalities. Topical methotrexate (MTX) with improved delivery methods may be a viable tool against certain localized dermatologic conditions. Regarding cutaneous warts, MTX either topical or intralesional is one of the promising lines of treatment.