Adropin a candidate diagnostic biomarker for cardiovascular disease in patients with chronic kidney disease.

Background: Chronic kidney disease (CKD) is a chief worldwide health concern that has a substantial financial impact on health systems, high rates of mortality and morbidity as well as cardiovascular disease (CVD) is a major cause of mortality in this population. Adropin is a unique hormone encoded by the energy homeostasis-associated (Enho) gene.

Aim Of The Work: We aimed to explore the efficacy of adropin as a diagnostic candidate biomarker for CVD in patients with CKD.

Potential biomarkers of ASD a target for future treatments: oxidative stress, chemokines, apoptotic, and methylation capacity.

Objectives: The study aimed to assess the effect of these biomarkers on a sample of children with autism spectrum disorder (ASD) to help in early diagnosis and intervention.

Methods: A total of 71 autistic patients and 65 normal controls were enrolled in this study. Their ages ranged from 5 to 11 years (mean ± SD 7.

Assessment of vitamin status; A, E and D in Egyptian neonates with IUGR: a cross sectional study.

Background: Neonates with intrauterine growth retardation (IUGR) may present with fatal complications and permanent serious consequences. Vitamin status may influence fetal development. In this study we assessed vitamin A, E and D concentrations in umbilical cord blood in newborns with IUGR.

Effect of ozone gas on viral kinetics and liver histopathology in hepatitis C patients.

Objectives: We examine how well ozone/oxygen gas therapy treats chronic hepatitis C patients with varying degrees of liver fibrosis. Also to study the effect of giving multiple anti-oxidants with the ozone/oxygen gas mixture, to see if this addition would have any additive or synergistic effect.

Methods: Two hundred and twenty three patients with chronic hepatitis C.

Clinical and diagnostic characteristics of non-alcoholic fatty liver disease among Egyptian children and adolescents with type1 diabetes.

Background: Type 1 diabetes mellitus (T1DM) patients are at an increased risk for non-alcoholic fatty liver disease (NAFLD). This study aimed to evaluate the clinical criteria associated with the diagnosis of Non-Alcoholic Fatty Liver Disease (NAFLD) among T1DM Egyptian children and adolescents.

Methods: 74 T1DM patients aged 8-18 year were enrolled in this cross sectional study.

Protective effect of hot peppers against amyloid β peptide and brain injury in AlCl-induced Alzheimer's disease in rats.

Objectives: This study investigated the therapeutic effect of red hot pepper ( annuum) methanolic extract in induced Alzheimer's disease using AlCl in male rats.

Materials And Methods: Rats were injected with AlCl intraperitoneally (IP) daily for two months. Starting from the 2nd month of AlCl, rats received, in addition, IP treatments with extract (25 and 50 mg/kg) or saline.

The role of the deficiency of vitamin B12 and folic acid on homocysteinemia in children with Turner syndrome.

Objectives: Premature atherosclerosis and ischemic heart disease represent a major cause of comorbidities among children with Turner syndrome. The identification of non-traditional risk aspects is crucial for the early identification and management of such comorbidities through establishing effective preventive measures. The aim of the study is to explore the role of the deficiency of vitamin B12, folic acid and homocysteine in children with Turner syndrome.

Acidic Exo-Polysaccharide Obtained from Bacillus sp. NRC5 Attenuates Testosterone-DMBA-Induced Prostate Cancer in Rats via Inhibition of 5 α-Reductase and Na/K ATPase Activity Mechanisms.

Bacillus sp. NRC5 is a new strain that grows in Egyptian beaches. This strain produces acidic exo-polysaccharide that have excellent antioxidant, anti-inflammatory and anti-tumor properties.

Inhibition of aluminum chloride-induced amyloid Aβ peptide accumulation and brain neurodegeneration by flower decoction.

Objectives: To investigate the potential therapeutic effect of flower decoction on aluminum chloride (AlCl)-induced neurotoxicity.

Materials And Methods: Rats received daily intraperitoneal injections of AlCl at 10 mg/kg for two months and were treated with decoction at 50 or 100 mg/kg or saline during the 2 month of the study. The control group received saline.

Bee venom attenuates neurodegeneration and motor impairment and modulates the response to L-dopa or rasagiline in a mice model of Parkinson's disease.

Objectives: This study aimed to investigate the effect of bee venom, a form of alternative therapy, on rotenone-induced Parkinson's disease (PD) in mice. Moreover, the possible modulation by bee venom of the effect of L-dopa/carbidopa or rasagiline was examined.

Materials And Methods: Rotenone (1.

Circulating glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase-L1 as markers of neuronal damage in children with epileptic seizures.

Background: Epilepsy is a common neurological disease that has a negative impact on physical, social, and cognitive function. Seizure-induced neuronal injury is one of the suggested mechanisms of epilepsy complications. We aimed to evaluate the circulating level of glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) as markers of neuronal damage in children with epilepsy and its relation to epilepsy characteristics.

The effect of low dose amphetamine in rotenone-induced toxicity in a mice model of Parkinson's disease.

Objectives: The effects of low dose amphetamine on oxidative stress and rotenone-induced neurotoxicity and liver injury were examined in a mice model of Parkinson's disease.

Materials And Methods: Male mice were treated with rotenone (1.5 mg/kg, every other day for two weeks, subcutaneously).

The role of K channel blockade and activation in the protection against neurodegeneration in the rotenone model of Parkinson's disease.

Aims: Several studies suggested that ATP-sensitive potassium channels (K) are potential therapeutic targets for protection against various neurodegenerative disorders, yet, there is an ongoing controversy regarding their role in Parkinson's disease (PD). Thus, the aim of the current study is to investigate the protective effect of K blockade and activation in the mice rotenone model of PD.

Main Methods: PD has been induced by 9 subcutaneous injections of rotenone (1.

Association of folic acid, vitamin B12, and intelligence scores in epileptic children.

Epilepsy is a serious childhood disease associated with cognitive impairment. Our aim was to investigate the possible association of serum folic acid, vitamin B12, and intelligence scores in epileptic children. A group of 30 children with established diagnosis of idiopathic epilepsy for at least one year as well as another group of 30 nonepileptic healthy children as the control group were recruited for analysis.

Correction to: Capsaicin Exerts Anti-convulsant and Neuroprotective Effects in Pentylenetetrazole-Induced Seizures.

The original version of this article unfortunately contains an error in the Y axis units in Fig. 1b, c (the symbol µ is not clear: µmol/g.tissue).

Acidic Exopolysaccharide Produced from Marine 3MS 2017 for the Protection and Treatment of Breast Cancer.

Purpose: This study was planned to investigate the anti-breast-cancer property of acidic exopolysaccharide produced from marine 3MS 2017 (BAEPS) in an animal model, which previously showed in-vitro anti-breast-cancer activity, by studying its potential participation in various targeted mechanisms.

Methods: Mammary carcinoma in female Sprague-Dawley rats, both in prophylactic and in curative designs, was chemically induced using 7,12-dimethylebenz-(a)-anthracene (DMBA). 3MS 2017 anti-breast-cancer property was evaluated by studying its effects on cancer-growth-rate-limiting enzymes (aromatase and Na/K ATPase), sexual hormones (estrogen and progesterone), antioxidant and inflammatory biomarkers (cyclooxygenase-1; COX-1 and cyclooxygenase-2; COX-2).

Capsaicin Exerts Anti-convulsant and Neuroprotective Effects in Pentylenetetrazole-Induced Seizures.

The transient receptor potential vanilloid-1 (TRPV1) receptor has been implicated in the development of epileptic seizures. We examined the effect of the TRPV1 agonist capsaicin on epileptic seizures, neuronal injury and oxidative stress in a model of status epilepticus induced in the rat by intraperitoneal (i.p.

Differential expression of miRNAs regulating NF-κB and STAT3 crosstalk during colitis-associated tumorigenesis.

Inflammatory bowel disease (IBD) is mostly responsible for the development of colitis-associated colon cancer. Of the several signaling pathways involved in colonic inflammation, the activation and crosstalk between NF-κB and STAT3 serve as the pivotal regulatory hubs that regulate epithelial tumorigenesis by linking inflammation with cancer development. Understanding the molecular mechanisms regulating the crosstalk between NF-κB and STAT3 will help in targeting these signaling pathways and halt epithelial tumorigenesis.

Polyneuropathy Associated with Severe Iron Overload and Oxidative Stress in β-Thalassemia Patients.

To investigate the frequency of peripheral neuropathy in patients with β-thalassemia, and to assess its relation to iron overload and oxidative stress. Sixty β-thalassemia patients with mean age of 19 ± 4.9 years were recruited.

[Omega-6/omega-3 ratio and cognition in children with epilepsy].

Introduction: Cognitive impairment is a common consequence of epilepsy in children. This study aimed to assess the ratio of omega-6 to omega-3 fatty acid levels and its impact on cognitive function in children with idiopathic epilepsy.

Patients And Methods: We performed a case-control study in 30 children with idiopathic epilepsy and 20 healthy children.

Oxidative stress contribution to attention deficit hyperactivity disorder in children with epilepsy.

Children with epilepsy have a high incidence of attention deficit hyperactivity disorder (ADHD). Oxidation stress and disturbed neurotransmitters are suggested mechanisms; however, their role is not fully explored. This study evaluates the association between circulating malondialdehyde as an oxidation stress marker, apelin neuropeptide, and ADHD in children with epilepsy.