Publications by authors named "Eman M Morgan"
ChlorTox scale assessment, greenness, and whiteness evaluation of selective spectrophotometric analysis of dimenhydrinate and cinnarizine.
Spectrochim Acta A Mol Biomol Spectrosc
November 2024
Article Synopsis
- * New selective spectrophotometric methods (DRD, DRE, DAE-DRE) were developed to accurately measure dimenhydrinate and cinnarizine in their presence of harmful impurities, demonstrating good accuracy and adherence to ICH guidelines.
- * The study incorporated various green assessment tools to evaluate the sustainability of these new methods compared to traditional HPLC methods, showing promise for improving quality control in pharmaceutical companies.
Article Synopsis
- - Diosmin (DIO) and hesperidin (HSP) are flavonoid glycosides utilized in preventing comorbidities related to COVID-19, and their analysis in a co-formulated tablet, Diosed C®, was developed using a new spectrophotometric method, combined with vitamin C.
- - The extraction process for vitamin C involved using de-ionized water, while DIO and HSP were extracted using two different solvents, with mathematical techniques applied to recover their spectra.
- - The extraction methods followed eco-friendly guidelines and were validated according to ICH standards, demonstrating effective and green analytical approaches for the pharmaceutical combination in question.
Background: Valaciclovir hydrochloride (VAL) is an essential antiviral prodrug used to cure various types of herpes. Analysis of VAL by different analytical techniques demonstrates a persuasive aspect that is favorable in quality control application.
Objective: This study describes a comparison between colorimetric and chromatographic (RP-high performance liquid chromatography (HPLC) and thin-layer chromatography (TLC)-densitometric) methods concerning selectivity and specificity for the determination of VAL in all possible degradation products (alkali- and acid-induced degradation products, namely aciclovir [ACI] and guanine [GUA], respectively) in their synthetic mixture and pharmaceutical formulations.