Publications by authors named "Eman Hamdi"
Saudi Pharm J
November 2023
Article Synopsis
- Pulmonary fibrosis (PF) represents the final stage of interstitial lung diseases (ILDs) characterized by lung damage and scarring, with treatment focused on slowing lung function decline rather than reversing damage.
- A gene variant, rs12979860, of the Interferon lambda-3 (IFN-λ3) was linked to an increased fibrosis risk in multiple organs, but its specific role in fibrogenesis remains unclear.
- The study investigated how IFN-λ3 influences ILDs by genotyping patients and healthy controls, showing that the CC genotype associates with higher IFN-λ3 expression and increased levels of inflammatory mediators, suggesting it may drive tissue fibrosis through a feedback loop of inflammation.
