Molecular networking-guided investigation of the secondary metabolome of four species and their neuroprotective potential for the mitigation of Alzheimer's disease.

Alzheimer's Disease (AD) is a fatal age-related neurodegenerative condition with a multifactorial etiology contributing to 70% of dementia globally. The search for a multi-target agent to hit different targets involved in the pathogenesis of AD is crucial. In the present study, the neuroprotective effects of four extracts were assessed in LPS-induced AD in mice.

Feature-Based Molecular Networking for the Exploration of the Metabolome Diversity of Common Egyptian Species in Relation to Their Cytotoxic Activity.

is a genus compromising over 250 herbaceous flowering species and is used traditionally to treat several ailments. Among the Egyptian species, was reported to be cytotoxic against multidrug-resistant cancer cells. In this context, we aimed to explore the metabolome of and compare it to other members of the genus in pursuance of identifying its bioactive principles.

Comparative Study on the Essential Oils from Five Wild Egyptian Species: Effective Extraction Techniques, Antimicrobial Activity and In-Silico Analyses.

The genus is recognized in folk medicine for anti-inflammatory, anti-itch, antitussive, purgative, astringent, and tonic activities. To study the chemical determinant for antimicrobial activity essential oils (EOs), five species were analyzed including: , , , and . Conventional hydro-distillation (HD) and microwave-assisted extraction (MAE), as new green technologies, were compared for the extraction of essential oils.

Cytotoxicity of 40 Egyptian plant extracts targeting mechanisms of drug-resistant cancer cells.

Background: The multidrug resistance (MDR) phenotype encounters a major challenge to the success of established chemotherapy in cancer patients. We hypothesized that cytotoxic medicinal plants with novel phytochemicals can overcome MDR and kill MDR-cells with similar efficacy as drug sensitive cells.

Purpose: We evaluated plant extracts from an unexplored ecosystem in Egypt with unusual climate and nutrient conditions for their activity against sensitive and multidrug-resistant cancer cell lines.

Euphosantianane A⁻D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant .

species are rich in diterpenes. A solvent extraction of , a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (⁻) as well as previously reported metabolites (⁻) that included three flavonoids. Isolated compounds were chemically characterized by spectroscopic analysis.

Molecular architecture and biomedical leads of terpenes from red sea marine invertebrates.

Marine invertebrates including sponges, soft coral, tunicates, mollusks and bryozoan have proved to be a prolific source of bioactive natural products. Among marine-derived metabolites, terpenoids have provided a vast array of molecular architectures. These isoprenoid-derived metabolites also exhibit highly specialized biological activities ranging from nerve regeneration to blood-sugar regulation.

Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review.

Natural products are structurally and biologically interesting metabolites, but they have been isolated in minute amounts. The syntheses of such natural products help in obtaining them in bulk amounts. The recognition of microbial biotransformation as important manufacturing tool has increased in chemical and pharmaceutical industries.