Publications by authors named "Eman El-Sayed Ebead"

This work explores the eco-friendly synthesis of various heterocycles from a piperidine-based compound () and explore their potential as antitumor agents. Ultrasonic irradiation was used to synthesize heterocycles like pyridone, thiophene and coumarin, with computational tools analyzing stability and biological interactions. Compounds and exhibit strong cytotoxic activity, surpassing doxorubicin.

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A series of arylidenes derivatives was synthesized under ultrasonic methodology Knoevenagel condensation reaction of cyanoacetohydrazide derivative with the appropriate aldehydes and/or ketone. The anticancer properties of the newly synthesized compounds were tested against four different human cancer cell lines (HEPG-2, MCF-7, HCT-116, and PC-3); compounds 5d and 6 demonstrated the greatest anticancer activity against all cancer cell lines. The MLR technique was used to create the QSAR model using five molecular descriptors (AATS6p, AATS7p, AATS8p, AATS0i, and SpMax4_Bhv).

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