Publications by authors named "Eman E Nasr"
Article Synopsis
- Researchers developed new piperazine derivatives to target human acetylcholinesterase (hAChE), butyrylcholinesterase (hBuChE), and β-amyloid aggregation, aiming for Alzheimer's treatment.
- Compound 10 emerged as the most effective inhibitor, with a half-maximal inhibitory concentration (IC) of 0.151 μM for hAChE and showed noncytotoxic effects in neuronal cell tests.
- Molecular docking studies indicated strong binding of compound 10 to critical sites of hAChE, suggesting its potential effectiveness in crossing the blood-brain barrier and protecting neurons from toxicity.
New quinolines substituted with various heterocycles and chalcone moieties were synthesized and evaluated as antitumor agents. All the synthesized compounds were in vitro screened against 60 human cancer cell lines. Compound 13 showed the highest cytotoxicity toward 58 cell lines, exhibiting distinct growth inhibition values (GI ) against the majority of them, including SR, HL-60 (TB) strains (leukemia), and MDA-MB-435 strains (melanoma), with GI values of 0.
View Article and Find Full Text PDF