Publications by authors named "Eman A H Al-Wattar"
Article Synopsis
- A nuclear localisation sequence (NLS) peptide, PAAKRVKLD, was linked to an iridium(iii) complex to create a conjugate that effectively enters human fibroblast cell nuclei.
- Incubation with concentrations of 80-100 μM of this conjugate showed significant cell uptake and confirmed nuclear localisation through co-localisation studies.
- In contrast, a similar iridium(iii) complex without the NLS peptide exhibited increased toxicity and poor cellular localization, indicating that the peptide is crucial for successful nuclear targeting.
