Publications by authors named "Emad George"
Anti-C1q antibodies in lupus nephritis and their correlation with the disease activity.
Saudi J Kidney Dis Transpl
April 2021
Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disorder. Renal involvement usually develops in the first few years of illness and should be detected early by periodic urine analysis and quantitation of proteinuria. The aim of our work was to evaluate the biological marker [anti-complement 1q antibodies (anti-C1q Ab)] in lupus nephritis (LN) patients and its correlation to SLE disease activity.
View Article and Find Full Text PDFAbout 40-50% of all patients with systemic lupus erythematosus (SLE) patients are associated with significant morbidity and a poor prognosis. The transforming growth factor β-1(TGF-β1) is a member of cytokines families which has emerged as an important player in the pathogenesis of autoimmune diseases, including SLE. In this study we aimed to evaluate TGF-β1 as a noninvasive diagnostic test for early diagnosis of LN and to assess the correlations between TGFβ-1 and clinic-pathologic characteristics as well as disease activity of SLE.
View Article and Find Full Text PDFIntroduction: Although microalbuminuria remains the gold standard for early detection of diabetic nephropathy (DN), it is not a sufficiently accurate predictor of DN risk. Thus, new biomarkers that would help to predict DN risk earlier and possibly prevent the occurrence of end-stage kidney disease are being investigated.
Objective: To investigate the role of zinc-alpha-2-glycoprotein (ZAG) as an early marker of DN in type 2 diabetic (T2DM) patients.
Article Synopsis
- The study investigates the phenomenon of occult hepatitis C infection (OCI) in Egyptian patients who achieved sustained virologic response (SVR) after treatment with direct-acting antiviral agents (DAAs).
- A total of 150 patients with chronic hepatitis C were tested for HCV RNA in their blood cells, revealing that 11.33% of them had positive results despite showing no active infection in serum.
- The research suggests that dual testing for HCV RNA in both serum and blood cells is essential to accurately assess the presence of OCI post-treatment, particularly after DAA therapy.
Mutations in succinate dehydrogense-B (SDHB) and the von Hippel-Lindau (VHL) genes result in an increased risk of developing chromaffin tumours via a common aetiological pathway. The aim of the present retrospective study was to compare the clinical phenotypes of disease in subjects developing chromaffin tumours as a result of SDHB mutations or VHL disease. Thirty-one subjects with chromaffin tumours were assessed; 16 subjects had SDHB gene mutations and 15 subjects had a diagnosis of VHL.
View Article and Find Full Text PDFObjective: Phaeochromocytomas and paragangliomas are familial in up to 25% of cases and can result from succinate dehydrogenase (SDH) gene mutations. The aim of this study was to describe the clinical manifestations of subjects with SDH-B gene mutations.
Design: Retrospective case-series.