Regression of hepatocellular carcinoma after treatment of hepatitis C: a case report.

Chronic hepatitis C induced cirrhosis predisposes to hepatocellular carcinoma (HCC). There is no data regarding the impact of hepatitis C treatment on HCC. We report a case of a 53-year-old man with chronic hepatitis C and HCC with lung metastasis who failed treatment with sorafenib but the tumor regressed after treatment of hepatitis C with ribavirin and sofosbuvir for 24 weeks.

Acquired inhibitors to factor VIII and fibrinogen in the setting of T-cell large granular lymphocyte leukemia: a case report and review of the literature.

Large granular lymphocyte (LGL) leukemia is an indolent lymphoproliferative malignancy which dysregulates humoral immunity and underlies the myriad autoimmune phenomena. We describe a 62-year-old woman with Felty's syndrome who developed a severe bleeding diathesis. Laboratory evaluation demonstrated acquired inhibitors to both factor VIII (FVIII) and fibrinogen, likely secondary to T-cell LGL leukemia.

Predictive value of immunization records and risk factors for immunization failure in internationally adopted children.

Objectives: To measure the predictive value of immunization records for protective immunity and identify risk factors for immunization failure.

Design: Prospective cross-sectional study, 2001-2006.

Setting: International Adoption Clinic, Rainbow Babies and Children's Hospital, Cleveland, Ohio.

Exposure to environmental tobacco smoke and the risk of colorectal cancer in a case-control study from Germany.

In a population-based case-control study in Germany, 540 incident cases of colorectal cancer (CRC) aged > or =30 years and 614 controls were recruited from January 2003 to June 2004. Information on risk factors of CRC and lifetime history of active smoking and exposure to environmental tobacco smoke (ETS) was obtained by personal interviews. This analysis is limited to never smokers (252 cases and 292 controls).

SULT1A1 genotype and susceptibility to colorectal cancer.

Several procarcinogens that are present in cooked red meat and tobacco smoke are substrates for sulfotransferase 1A1 (SULT1A1). The association between environmental exposures and colorectal cancer risk may be modified by individual differences in the metabolism. Thus, we investigated the effect of a common polymorphism in the SULT1A1 gene associated with decreased enzyme activity on the susceptibility to colorectal cancer in a population-based case-control study.

CYP17 genotype modifies the association between lignan supply and premenopausal breast cancer risk in humans.

Cytochrome P450c17alpha (CYP17) has been associated with alterations in steroid hormone levels and premenopausal breast cancer risk and could modify the association between phytoestrogen intake and breast cancer risk. We examined plasma concentrations of enterolactone and genistein, estimated dietary phytoestrogen intake, CYP17 5'-UTR MspA1 genetic polymorphism, and breast cancer risk in 267 premenopausal breast cancer patients and 573 age-matched population controls from Germany. Multivariate logistic regression was used to estimate breast cancer risk associated with quartiles of phytoestrogen intake by genotype and to investigate gene-nutrient interactions.

Cigarette smoking and colorectal cancer risk in Germany: a population-based case-control study.

Studies have shown fairly consistent positive relationships between smoking and risk of colorectal adenomas, but have yielded inconsistent results for colorectal cancer. Issues relating to the duration, cumulative dose of smoking and the effect of smoking cessation on colorectal cancer risk still need clarification. In a population-based case-control study in Germany, we recruited 540 incident cases of colorectal cancer and 614 controls matched to cases by sex, 5-year age groups and county of residence from January 2003 to June 2004.

Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption.

N-Acetyltransferases 1 and 2 (NAT1 and NAT2), both being highly polymorphic, are involved in the metabolism of aromatic and heterocyclic aromatic amines present in cigarette smoke and red meat cooked by high-temperature cooking techniques. We investigated the effect of differences in acetylation capacity, determined by NAT1 and NAT2 genotypes, on colorectal cancer risk associated with exposure to tobacco smoke or red meat consumption. In this population-based case-control study in Germany, 505 patients with incident colorectal cancer and 604 age- and sex-matched control individuals with genotyping data and detailed risk factor information were included.

CYP17 5'-UTR MspA1 polymorphism and the risk of premenopausal breast cancer in a German population-based case-control study.

Introduction: Studies on the association between the cytochrome P450c17alpha gene (CYP17) 5'-untranslated region MspA1 genetic polymorphism and breast cancer risk have yielded inconsistent results. Higher levels of estrogen have been reported among young nulliparous women with the A2 allele. Therefore we assessed the impact of CYP17 genotypes on the risk of premenopausal breast cancer, with emphasis on parity.