Beta defensins (β-defensins) are antimicrobial peptides mainly produced by epithelial cells to protect the skin and other organs from harmful microorganisms.*
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Human β-defensin 2 (HBD2) is linked to allergic reactions and is found at higher levels in patients with skin diseases like atopic dermatitis and psoriasis, contributing to conditions like chronic spontaneous urticaria (CSU).*
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Despite its potential as a marker for inflammation and a possible therapeutic target, more research is needed to understand the mechanisms behind elevated HBD2 levels in allergic skin diseases.*