Publications by authors named "Elzbieta Semik-Grabarczyk"
Vascular injury represents one of the most frequent lesions in systemic lupus erythematosus (SLE). The aim of the study was to assess the influence of anti-endothelial cell antibodies (AECAs) on the development of endothelial cell (EC) activation, dysfunction and subsequent vasculitis in women with SLE. Fifty six women with SLE were divided into 2 subgroups, i.
View Article and Find Full Text PDFBackground: Lymphoplasmacytic lymphoma is a rare non-Hodgkin's lymphoma, occurring mostly in the elderly. It develops slowly and leads to malignant proliferation of lymphoid line cells in the bone marrow, lymph nodes and spleen. It may also affect nerve roots and meninges; some patients develop sensorimotor polyneuropathy which may precede general symptoms of lymphoma.
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- The study investigated the presence of urogenital mycoplasmas in women with systemic lupus erythematosus (SLE) compared to healthy controls.
- Out of 36 women with SLE, 36.1% tested positive for mycoplasmas, while 25% of 100 healthy controls were positive, with U. parvum being the most common in both groups.
- Despite no significant difference in occurrence between the two groups, mycoplasmas should still be considered as a possible cause of urogenital infections when symptoms arise but the cause is unclear.
Interdependencies among Selected Pro-Inflammatory Markers of Endothelial Dysfunction, C-Peptide, Anti-Inflammatory Interleukin-10 and Glucose Metabolism Disturbance in Obese Women.
Int J Med Sci
April 2017
Background: Currently increasing importance is attributed to the inflammatory process as a crucial factor responsible for the progressive damage to vascular walls and progression of atherosclerosis in obese people. We have studied the relationship between clinical and biochemical parameters and C-peptide and anti-inflammatory IL-10, as well as selected markers of inflammation and endothelial dysfunction such as: CCL2, CRP, sICAM-1, sVCAM-1 and E-selectin in obese women with various degree of glucose metabolism disturbance.
Material And Methods: The studied group consisted of 61 obese women, and 20 normal weight, healthy volunteers.
Cogan syndrome is a persistent disease with the autoimmunologic background connected with vasculitis. It can be diagnosed by symptoms such as interstitial keratitis, optic nerve dysfunction and nervus acusticus dysfunction with subsequent hearing impairment or deafness. In its course, such systemic symptoms frequently occur: exhaustion, weight loss and joint pain.
View Article and Find Full Text PDFSystemic lupus erythematosus (SLE) is a chronic autoimmune disease, with not fully understood, complex origin. Several factors are suspected of involvement in the development of the disease. Genetic predisposition, environmental factors, some drugs, estrogens, cigarette smoking and ultra violet radiation seems to be the most important among them.
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- The study aimed to determine how common depression is among obese individuals before they start a weight-loss program.
- 173 obese participants were assessed using Beck's Depression Inventory, revealing severe depression in 84 subjects, mild depression in 65, and 24 subjects with no depression.
- There was a significant correlation between depression severity and BMI, indicating that higher levels of obesity are associated with increased depression levels.
Article Synopsis
- Adult obesity is linked to depression, particularly in women, but the relationship between the two—whether one causes the other—is still uncertain.
- Researchers assessed depression levels in 63 obese women using Beck's questionnaire, then categorized them into groups based on mood status: no depression, mild depression, and severe depression.
- Despite these classifications, there were no significant differences in inflammation markers (TNF-alpha, leptin, IL-6) or other health metrics related to body composition among the mood groups, suggesting that these factors do not impact depression levels in obese women.
Introduction: The aim of the present study was to examine how weight loss treatment modulates plasma concentrations of ghrelin and insulin-like growth factor 1 (IGF-1) in obese women and to determine whether there is any association with possible changes in plasma concentrations of these hormones after weight loss.
Material And Methods: The study group consisted of 22 obese women without additional disease (age 40.6 +/- 12.
Article Synopsis
- The study aimed to assess how a modest weight loss affects certain inflammatory markers (TNF-alpha, sTNFRs, and IL-6) in obese women with polycystic ovary syndrome (PCOS).
- It involved 15 obese women who followed a low-calorie diet and exercise program, with various biochemical markers measured before and after a 10% weight loss.
- Results showed no significant changes in the inflammatory markers post-treatment, suggesting that more substantial weight loss may be required to improve inflammation and ovarian function in these patients.
Introduction: The aim of the present study was to examine the response of plasma orexin and ghrelin to the oral glucose tolerance test (OGTT) in obese women without additional disease.
Material And Methods: The study group comprised 15 obese women aged 30.4+/-9.
The aim of the present study was to determine serum concentrations of visfatin in obese women in comparison to normal-weight controls. Study subjects were 21 obese women without additional disease (age, 29.0+/-4.
View Article and Find Full Text PDFIntroduction: Interleukine-6 (IL-6) is one of the cytokines, excreting by adipocytes, which increases in obesity. These cytokines participate in very complicated mechanisms of developing insulin resistance that accompany obesity. The aim of the study was to: 1) evaluate the influence of weight loss on insulin resistance and serum concentration of IL-6, 2) evaluate the hypothetical association between serum concentration of IL-6 and the improvement of insulin sensitivity in obese women after weight loss.
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