Overexpression of a single ORF can extend chronological lifespan in yeast if retrograde signaling and stress response are stimulated.

Systematic collections of single-gene deletions have been invaluable in uncovering determinants of lifespan in yeast. Overexpression of a single gene does not have such a clear outcome as cancellation of its function but it can lead to a variety of imbalances, deregulations and compensations, and some of them could be important for longevity. We report an experiment in which a genome-wide collection of strains overexpressing a single gene was assayed for chronological lifespan (CLS).

Correction to: Gene overexpression screen for chromosome instability in yeast primarily identifies cell cycle progression genes.

In the original publication, 'Frumkin JP et al.' reference was missed to include in the reference list. The complete reference should read as below.

Gene overexpression screen for chromosome instability in yeast primarily identifies cell cycle progression genes.

Loss of heterozygosity (LOH) in a vegetatively growing diploid cell signals irregularity of mitosis. Therefore, assays of LOH serve to discover pathways critical for proper replication and segregation of chromosomes. We screened for enhanced LOH in a whole-genome collection of diploid yeast strains in which a single gene was strongly overexpressed.