Publications by authors named "Elzbieta Pirianowicz-Chaber"
A series of potential anticonvulsants have been synthesized. There are eight fluorobenzylamides and three chlorobenzylamides of isocyclic or heterocyclic acids. Two not halogenated benzylamides were also synthesized to compare the effect of halogenation.
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- A series of benzylamides derived from isocyclic and heterocyclic acids was synthesized and evaluated for their anticonvulsant properties in a study by the NIH.
- Almost all derivatives of heterocyclic acids displayed anticonvulsant activity, while isocyclic acid derivatives were found to be inactive.
- Notably, 2-furoic acid benzylamide demonstrated the most promise, showing effective results in seizure tests with a favorable protective index.
Qualitative and quantitative methods of analysis of three new amino-acid derivatives potential anticonvulsants of low neurotoxicity: picolinic acid benzylamide (1), nicotinic acid benzylamide (2) and isonicotinic acid benzylamide (3) were developed. Qualitative analysis includes characteristic reactions, chromatographic (TLC) investigations, IR and UV spectra interpretation. The quantitative analysis involves spectophotometric, chromatographic (HPLC) and acidimetric methods.
View Article and Find Full Text PDFQualitative and quantitative methods of analysis of two new amino acid derivatives, potential anticonvulsants of low neurotoxicity: N-acetyl-gamma-aminobutyric acid benzylamide (1) and N-melhyl-gamma-aminobutyric acid benzylamide (2) were developed. Qualitative analysis includes characteristic colour reactions, chromatographic (TLC) investigations, IR and UV spectra interpretation and quantitative analysis involves spectrophotometric, chromatographic (HPLC). acidimetric and argentomeric methods.
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