Diagnosing Primary Hyperparathyroidism in Pregnancy: A Case of Altered Parathyroid Hormone Degradation in Pregnancy.

Diagnosing primary hyperparathyroidism in pregnancy is difficult due to pregnancy-related changes in parathyroid hormone (PTH); calcium; 1,25 vitamin D; and renal calcium excretion. Parathyroid hormone-related peptide (PTHrP) produced by the placenta adds additional complexity. Our case is the first to demonstrate an increased rate of PTH degradation within a pregnant individual who returned unexpectedly low PTH levels.

Evaluation of the Atellica TnIH cardiac troponin I assay and assessment of biological equivalence.

Objectives: We evaluated the analytical performance characteristics and the biological equivalence of the Atellica TnIH assay.

Methods: Precision, detection capability, linearity, and sex specific 99 percentiles were determined . Classification of patients relative to the 99 percentiles was used to assess biological equivalence.

Pre-analytical mysteries: A case of severe hypervitaminosis D and mild hypercalcaemia.

We describe a case of severe hypervitaminosis D and mild hypercalcaemia in a 68-year-old woman who presented with fatigue and weight loss. Her 25-hydroxy vitamin D (25OHD) was > 400 nmol/L (50-150) and corrected serum calcium was 2.83 mmol/L (2.