Publications by authors named "Elza Tjio"
Prostate cancer has substantial heterogeneity in clinical outcomes and therapeutic responses, posing challenges in predicting disease progression and tailoring treatment strategies. Recent studies have highlighted the potential prognostic value of evaluating the tumor microenvironment, including the presence of a histologically overt stromal response (HOST-response) characterized by peri-glandular stromal changes and architectural distortions. This retrospective study examined patient records from The Cancer Genome Atlas database to identify genomic alterations associated with the HOST-response in prostate cancer.
View Article and Find Full Text PDFPurpose: Given the variable clinical course of prostate cancer and the limitations of current prognostic factors, this study was conducted to investigate the impact of a histologically overt stromal response (HOST-response) to prostate cancer on clinical outcomes after radical prostatectomy.
Methods: This retrospective analysis utilized The Cancer Genome Atlas (TCGA) to evaluate data from individuals with a confirmed diagnosis of prostate cancer who underwent radical prostatectomy and had available pathology slides. These slides were assessed for the presence of a HOST-response, similar to desmoplasia.
Article Synopsis
- - This study investigates how cribriform pattern 4 (CP4) affects clinical outcomes in prostate cancer patients and its molecular characteristics based on data from The Cancer Genome Atlas.
- - Analyzing 394 patients, the research found that 32.74% had CP4, which was linked to significantly lower progression-free survival (PFS) rates after surgery compared to those without CP4.
- - The study highlights that patients with CP4 have unique genomic features and suggests they may need additional treatments after surgery, urging further clinical trials for these individuals.