Publications by authors named "Elyse McGlumphy"
The relationship between intraocular pressure and glaucoma: An evolving concept.
Prog Retin Eye Res
November 2024
Article Synopsis
- * The article discusses various aspects of IOP including its determinants, measurement technologies, and the necessity for continuous monitoring as it can significantly influence treatment outcomes in glaucoma patients.
- * Evidence suggests that IOP varies widely throughout the day, and monitoring IOP outside of clinical visits could provide critical insights, paralleling successful strategies used in managing other health conditions like hypertension and diabetes.
Objective: To examine the longitudinal postoperative outcomes of open versus closed conjunctiva implantation of the XEN45 gel stent.
Design: Retrospective multicenter study.
Subjects: One hundred ninety-three patients with glaucoma underwent XEN45 implantation via an open or closed conjunctiva approach.
Objective: To compare outcomes following Ahmed-FP7 (AGI-FP7), Baerveldt-250mm (BGI-250), or Baerveldt-350mm (BGI-350) implantation.
Methods And Analysis: Retrospective cohort study comprising 800 eyes from 800 individuals who underwent surgery 1 January 2016-31 December 2020 at a tertiary-care institution. Data were extracted from standardised fields in the electronic health record.
Objective: To evaluate family and maternity leave policies and examine the social and professional impacts on female ophthalmologists.
Participants: Participants were recruited through the Women in Ophthalmology online list-serv to complete a survey evaluating maternity leave policies and their impacts. Survey questions were repeated for each birth event after medical school for up to five birth events.
Purpose: To describe twelve cases in which home intraocular pressure (IOP) monitoring complimented clinical decision-making in glaucoma management.
Observations: Home IOP monitoring elucidated peaks and amplitudes of variation that were not captured by in-clinic IOP measurements during the pre- or post-interventional period.
Conclusions & Importance: Home monitoring can establish pre-treatment IOP patterns that are not evident during in-clinic measurements.
Purpose: To compare electronically measured adherence with topical corticosteroid (CS) drops with outcomes of glaucoma surgery.
Design: This prospective cohort study included eyes undergoing surgery from August 2019 to January 2021 and followed for up to 1 year.
Participants: All patients were recruited from the Glaucoma Center of Excellence at the Wilmer Eye Institute, Johns Hopkins.
Purpose: This study examined characteristics of intraocular pressure (IOP) as measured during home tonometry in comparison with in-clinic tonometry in patients with glaucoma.
Design: Retrospective cross-sectional study of glaucoma patients who completed 1 week of self-tonometry at a single academic center.
Participants: Patients with glaucoma who completed home tonometry trials with the iCare HOME tonometer (iCare USA) for any reason.
Purpose: To describe the efficacy and safety of open versus closed conjunctival implantation of the XEN45 Gel Stent (Allergan Inc).
Design: Retrospective, multicenter study.
Participants: A total of 137 patients with glaucoma who underwent XEN45 implantation via open or closed conjunctival methods.
Purpose: Although Fuchs corneal dystrophy (FCD) is considered an eye disease, a small number of studies have identified genes related to both FCD and hearing loss. Whether FCD is related to hearing loss is unknown.
Method: This is a case-control study comparing pure-tone audiometry hearing thresholds in 180 patients with FCD from a hospital-based ophthalmology clinic with 2,575 population-based controls from a nationally representative survey, the National Health and Nutrition Examination Survey (from cycles 2005-06 and 2009-10).
Purpose: Corneal endothelial cell density (ECD) is an important measure for determining suitability for transplantation. Although age has been correlated with ECD, the impact of sex and ethnicity is unclear.
Methods: Corneal donor information from SightLife Eye Bank was collected between 2012 and 2016.
A 31-year-old woman with a history of unusual appearing recurrent linear corneal epithelial defects and subepithelial scaring in both eyes underwent 2 years of evaluation and treatment. It was eventually discovered that the patient was using a sleep mask with excessive fabric pilling, which was found to be the source of her chronic epitheliopathy. After discontinuation of the sleep mask, the patient experienced complete resolution of symptoms.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the relationship between retroillumination photography analysis (RPA) and clinical grading of guttae in Fuchs corneal dystrophy using slit-lamp biomicroscopy.
- Researchers manually counted guttae in 95 affected corneas and correlated these counts with Krachmer scale ratings, revealing a significant increase in guttae numbers at higher severity levels.
- The results indicate a strong correlation between RPA and clinical grading, highlighting RPA's effectiveness in accurately assessing disease severity, especially in advanced cases.
Article Synopsis
- Fuchs corneal dystrophy (FCD) is a genetic condition affecting the cornea and is a leading reason for corneal transplants in the U.S., linked to the LOXHD1 gene.
- Scientists conducted next-generation sequencing in a family with FCD and discovered a specific mutation in the LOXHD1 gene that correlates with the disease.
- Further studies found additional mutations in LOXHD1 in other affected individuals, suggesting that various mutations can cause different disease symptoms related to FCD.
Purpose: To investigate the clinical and genetic features of late-onset Fuchs corneal dystrophy (FCD) on Tangier, an island in the Chesapeake Bay with an isolated population of approximately 500 individuals.
Design: Observational, cross-sectional study.
Methods: A total of 156 individuals born to inhabitants of Tangier Island volunteered to undergo ophthalmic evaluation.
Purpose: Fuchs corneal dystrophy (FCD) is an autosomal dominant disease of the corneal endothelium with variable penetrance and expressivity. Recently, rs613872, an intronic variation of TCF4 associated with late-onset FCD, was reported. The present study was undertaken to examine this association in our cohort of FCD patients, to assess the significance of this finding, and to investigate the candidacy of TCF4 in the context of the mapped FCD2 locus.
View Article and Find Full Text PDFAge-severity relationships in families linked to FCD2 with retroillumination photography.
Invest Ophthalmol Vis Sci
December 2010
Purpose: Fuchs corneal dystrophy (FCD) is a progressive disorder of the corneal endothelium and is pathologically defined by the presence of guttae, which are excrescences of the Descemet membrane. The present study was undertaken to investigate the age-severity relationship of the FCD2-linked disease phenotype using retroillumination photography and to compare it with the characteristics of FCD1.
Methods: Two large families with multiple affected members were recruited.