The Molecular Chaperone HSP90 Promotes Notch Signaling in the Germline of .

In a genetic screen to identify genes that promote GLP-1/Notch signaling in germline stem cells, we found a single mutation, , defining a gene called causes several defects in the soma and the germline, including paralysis during larval development, sterility, delayed proliferation of germline stem cells, and ectopic germline stem cell proliferation. Whole genome sequencing identified as an allele of , previously known as , which encodes the ortholog of the cytosolic form of HSP90. This protein is a molecular chaperone with a central position in the protein homeostasis network, which is responsible for proper folding, structural maintenance, and degradation of proteins.

Using GIS and secondary data to target diabetes-related public health efforts.

Objectives: To efficiently help communities prevent and manage diabetes, health departments need to be able to target populations with high risk but low resources. To aid in this process, we mapped county-level diabetes-related rates and resources/use using publicly available secondary data to identify Michigan counties with high diabetes prevalence and low or no medical and/or community resources.

Methods: We collected county-level diabetes-related rates and resources from Web-based sources and mapped them using geographic information systems (GIS) software.