Pharmacological therapy in gestational diabetes - a comparison between insulin and oral therapy.

Background: The appropriate medical treatment for gestational diabetes mellitus (GDM) is controversial and recommendations vary between different organizations.

Objective: To compare the safety and efficacy of glyburide and insulin as treatments for GDM.

Methods: Retrospective analysis of all pregnant women diagnosed with GDM and treated with either glyburide or insulin.

Characterization of women with gestational diabetes who failed to achieve glycemic control by lifestyle modifications.

Purpose: To identify specific characteristics of women diagnosed with gestational diabetes who failed to achieve good glycemic control by lifestyle modifications only.

Methods: Retrospective analysis of women carrying a singleton pregnancy diagnosed with gestational diabetes. The cohort included 314 women who achieved good glycemic control by lifestyle modifications and 328 women who required anti-diabetic medications.

Surgically treated ovarian endometriosis association with BRCA1 and BRCA2 mutations.

Endometriosis is associated with an increased risk of ovarian cancer. Few studies have also shown increased risk of breast cancer. BRCA1/2 mutations are linked to an increased risk of breast and ovarian cancers but their relation to endometriosis is unknown.