Publications by authors named "Elvis Kraja"
Article Synopsis
- The study aimed to investigate the effectiveness of antenatal corticosteroids (ANS) on male and female fetuses without anomalies, specifically regarding mortality and short-term health outcomes in infants born before 32 weeks of gestation.
- In analyzing 210 preterm infants, the results revealed that male infants exposed to ANS had a lower mortality rate (11%) compared to females (23%), but no significant differences were found in other health issues like intraventricular hemorrhage or respiratory distress syndrome, except for a higher rate of bronchopulmonary dysplasia in males.
- The research concluded that ANS does not influence mortality rates in female fetuses, suggesting future studies could explore personalized ANS treatment based on fetal sex.
Article Synopsis
- - The study aimed to explore the relationship between antenatal magnesium sulfate (MgSO) exposure and the occurrence of patent ductus arteriosus (PDA) in preterm infants, particularly those born between 24 and 31 weeks of gestation.
- - Results showed that while antenatal MgSO exposure was linked to a higher risk of hemodynamically significant PDA (hsPDA), it did not influence the rates of PDA ligation or the presence of open PDA at discharge.
- - The findings suggest that high doses of MgSO (over 20g) might increase hsPDA risk, but more research is necessary to clarify how the dosage impacts these outcomes.
Article Synopsis
- The study assessed the effectiveness of the Neonatal Sequential Organ Failure Assessment (nSOFA) scoring system in predicting mortality in very preterm infants with late-onset sepsis (LOS).
- It analyzed data from 120 episodes of LOS in infants born before 32 weeks' gestation, comparing nSOFA scores at various time points and found that higher scores were linked to increased mortality risk.
- The results suggest that nSOFA is a viable tool for predicting health outcomes in extremely preterm infants, with potential enhancements through additional factors like birth weight and immune cell counts.
Comparison of Definitions for Bronchopulmonary Dysplasia: A Cohort Study.
Z Geburtshilfe Neonatol
February 2023
Article Synopsis
- A study compared the definitions of bronchopulmonary dysplasia (BPD) from the National Institute of Child Health and Human Development (NICHD) from 2001 and 2018 to assess incidence and outcomes in preterm infants born before 32 weeks' gestation.
- The incidence of BPD was found to be higher (49%) with the 2001 definition compared to 32% with the 2018 definition; both definitions correlated with factors like gestational age and birth weight.
- The NICHD 2018 definition demonstrated similar sensitivity and negative predictive value but higher specificity for predicting late death and respiratory outcomes, making it a more effective indicator for long-term respiratory health in infants.
Objective: Non-invasive respiratory support strategies are known to reduce the complications of invasive mechanical ventilation in preterm infants. Nasal continuous positive airway pressure (NCPAP) and nasal intermittent positive pressure ventilation (NIPPV) are commonly used ones. The recent meta-analyses indicated that early NIPPV did appear to be superior to NCPAP for decreasing respiratory failure and the need for intubation among preterm infants with respiratory distress syndrome (RDS).
View Article and Find Full Text PDFBackground: Continuous kidney replacement therapies (CKRT) have been reported to be an effective approach to removing toxic metabolites in inborn errors of metabolism (IEM). The present study evaluates efficiency and complications of CKRT in children with IEM.
Methods: Patients diagnosed with IEM who underwent CKRT in pediatric and neonatal intensive care units were analyzed.