Natural antioxidants protect against cadmium-induced damage during pregnancy and lactation in rats' pups.

Free-radicals production is involved in the toxicity of cadmium. The aim of this study was to determine whether biochemical changes occurred in the liver and kidney of cadmium exposed pups during gestation and lactation, and additionally to investigate the potential beneficial role of the administration of certain antioxidants against cadmium exposure damage. Pregnant Wistar rats received the following treatments as drinking water: (1) Distilled water; (2) Cadmium (10 mg/L); (3) Cadmium + Zinc (20 mg/L) + vitamins A (50000 U/L), C (2 g/L), E (500 mg/L), and B(6) (500 mg/L); (4) Vitamins + Zinc solution.

Do oral antimuscarinic drugs carry an increased risk of acute urinary retention?

Purpose: We determined whether men treated with oral antimuscarinics are at increased risk for acute urinary retention.

Materials And Methods: In this population based, retrospective cohort study using a nested case-control design we analyzed data from a large primary care database containing patient information entered by general practitioners in the United Kingdom. Our study cohort comprised men 20 to 84 years old.

Natural antioxidants protect against lead-induced damage during pregnancy and lactation in rat's pups.

The aim of this study was to add further evidence to the biochemical changes produced in lead-exposed pups and to investigate the potential role of natural antioxidants against the lead-induced damage. Pregnant Wistar rats received treatments with drinking water, divided into four groups, as follows: (1) distilled water; (2) lead (300mg/L); (3) lead+Zn (20mg/L)+vitamins A (50,000U/L), C (2g/L), E (500mg/L) and B(6) (500mg/L); and (4) vitamins+Zn solution. We found a significant decrease in haemoglobin and haematocrit values as well and an increase in haemolysis among lead-exposed pups.

The safety of rosuvastatin in comparison with other statins in over 100,000 statin users in UK primary care.

Purpose: To compare mortality and the incidence of hospitalization for myopathy, rhabdomyolysis, acute renal failure and acute liver injury in patients receiving rosuvastatin and those taking other statins.

Methods: Patients prescribed a statin that they had not used before were selected from the UK General Practice Research Database (GPRD) and followed up from 1 April 2003 to 31 December 2005.

Results: We studied 10 289 patients on rosuvastatin and 117 102 taking other statins.

Toxic effects of perinatal lead exposure on the brain of rats: involvement of oxidative stress and the beneficial role of antioxidants.

The aim of this study was to determine whether changes in the activities of antioxidant enzymes occur in the brain of lead-exposed rats (300mgPb/L in drinking water) and to investigate the potential benefit of the administration of some natural antioxidants (Zn 20mg/L+vitamins A 50.000U/L, C 2g/L, E 500mg/L and B6 500mg/L) during pregnancy and lactation. Lead exposure caused a significant increase in brain TBARS (23%) vs.