Publications by authors named "Elvio A Mazzotta"
We describe the clinical course of a 65-year-old male patient who suffered from hydrocarbon-induced myelodysplasia and was successfully treated with the thrombopoietin receptor agonist (TPO-RA), romiplostim. Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis, cytopenias, and increased risk of leukemic transformation. Here, we present a clinical vignette of MDS-associated thrombocytopenia refractory to first-line drugs as well as the TPO-RA, eltrombopag.
View Article and Find Full Text PDFHistamine-dependent interactions between mast cells, glia, and neurons are altered following early-life adversity in mice and humans.
Am J Physiol Gastrointest Liver Physiol
December 2020
Article Synopsis
- Early-life adversity, such as neonatal maternal separation in mice, is linked to changes in the relationship between mast cells and enteric glia, which may lead to bowel disorders later in life.
- The study found that stress increases mast cell numbers near myenteric ganglia and enhances histamine production, affecting how glia respond to these cells.
- Importantly, while stress modifies glial responses and protein expression, it does not lead to neurodegeneration, suggesting that altered mast cell-glial signaling could be a key factor in how early-life stress impacts gut health.