Publications by authors named "Elvin A Akhmatov"
Article Synopsis
- The study investigates how a bovine serum albumin conjugate of a synthetic hexasaccharide derived from Streptococcus pneumoniae affects the innate immune response and antibody production in mice.
- The glyco-conjugate (GC) administration led to increased TLR2-expressing cells and matured dendritic cells, resulting in elevated pro-inflammatory cytokines in the mice's blood.
- The presence of aluminum hydroxide enhanced the immune response, leading to higher levels of specific IgG antibodies after the second immunization and facilitated the production of memory antibodies with a booster shot, suggesting potential improvements in vaccine design.
Article Synopsis
- Tγδ and B1 lymphocytes quickly respond to mucosal pathogens by producing antibodies, crucial for immediate immune protection without needing extra signals.
- The study examined how different methods (subcutaneous, intranasal, and oral) to deliver the immunomodulator Immunovac-VP-4 affected these lymphocytes, revealing increases in Tγδ and B1 cell levels across various lymphoid tissues.
- Mucosal application of Immunovac-VP-4 not only activated immune responses in local tissues but also enhanced migration of immune cells to distant organs, contributing to both local and systemic immunity.
