Publications by authors named "Eluzia Castro Peres-Emidio"
The Th2 Response and Alternative Activation of Macrophages Triggered by Is Linked to Increased Morbidity and Mortality Due to Cryptococcosis in Mice.
J Fungi (Basel)
September 2023
Cryptococcosis is a systemic mycosis that causes pneumonia and meningoencephalitis. Strongyloidiasis is a chronic gastrointestinal infection caused by parasites of the genus Cryptococcosis and strongyloidiasis affect the lungs and are more prevalent in the same world regions, i.e.
View Article and Find Full Text PDFPrior infections can provide protection or enhance susceptibility to a subsequent infection through microorganism's interaction or host immunomodulation. Staphylococcus aureus (SA) and Cryptococcus gattii (CG) cause lungs infection, but it is unclear how they interact in vivo. This study aimed to study the effects of the primary SA lung infection on secondary cryptococcosis caused by CG in a murine model.
View Article and Find Full Text PDFRandomized, phase 1/2, double-blind pioglitazone repositioning trial combined with antifungals for the treatment of cryptococcal meningitis - PIO study.
Contemp Clin Trials Commun
June 2021
Article Synopsis
- - The study investigates the effectiveness and safety of pioglitazone (PIO), an antidiabetic drug, in combination with standard antifungal treatments for cryptococcosis, aiming to improve patient outcomes since current treatments have high toxicity and limited availability in Brazil.
- - Conducted as a phase 1/2 randomized, double-blind, placebo-controlled trial, patients in Belo Horizonte will be divided into three groups receiving either a placebo, PIO 15 mg/day, or PIO 45 mg/day during treatment to assess changes in mortality, fungal burden, and side effects over a follow-up period of 60 days.
- - The research aims to establish PIO as a beneficial adjuvant therapy, potentially increasing survival rates
Cryptococcosis is a life-threatening fungal infection, and its current treatment is toxic and subject to resistance. Drug repurposing represents an interesting approach to find drugs to reduce the toxicity of antifungals. In this study, we evaluated the combination of N-acetylcysteine (NAC) with amphotericin B (AMB) for the treatment of cryptococcosis.
View Article and Find Full Text PDFApproximately 180,000 people worldwide die from cryptococcosis each year, probably due to the ineffectiveness and toxicity of drugs currently available to treat the disease. Amphotericin B (AMB) is effective for killing the fungus, but has serious adverse effects linked to excessive production of reactive oxygen species which compromise renal function. Pioglitazone (PIO) is a peroxisome proliferator-activated receptor-γ agonist widely repositioned as an adjuvant of various drugs that have toxic effects due to its antioxidant and anti-inflammatory effects.
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