Publications by authors named "Elson Neto"
Introduction Unresectable pancreatic tumors are frequently diagnosed. Initial treatment is carried out with chemotherapy. Eventually, in selected cases, radiotherapy may be used to improve local control rates and relieve the symptoms.
View Article and Find Full Text PDFObjective: Focal stereotactic radiosurgery to the surgical cavity lowers local recurrence after resection of brain metastases (BM). To evaluate local control (LC) and brain disease control (BDC) after intraoperative radiotherapy (IORT) for resected BM.
Methods: Adult patients with completely resected single supratentorial BM were recruited and underwent IORT to the cavity with a prescribed dose of 18 Gy to 1 mm-depth.
Purpose: This study aimed to evaluate the association of bolus and 2-stage breast reconstruction complications, and whether the dosimetric advantage translates into improvements in local control.
Methods And Materials: We retrospectively analyzed data from 2008 to 2019 of women who underwent a mastectomy and a planned 2-stage breast reconstruction, followed by adjuvant radiation therapy. We reviewed all data from medical records and radiation plans regarding patient characteristics, diagnoses, surgeries, complications, pathology, staging, systemic therapy, radiation therapy, and outcomes, and compared complication rates according to bolus usage.
Article Synopsis
- Patients with recurrent squamous cell carcinoma of the head and neck often face aggressive disease, and while surgical resection is standard, the effectiveness of immediate post-operative stereotactic ablative radiotherapy (PO-SABR) remains unclear.
- A study at the AC Camargo Cancer Center analyzed 11 patients treated with PO-SABR between 2018 and 2021, revealing 2- and 4-year disease-free survival (DFS) rates of 62.3% and 41.6%, and overall survival (OS) rates of 80.0% and 53.3%, respectively.
- Findings suggest that a more aggressive treatment combining salvage surgery with immediate PO-SABR may benefit select patients
Heterogeneity of HER2 Expression in Circulating Tumor Cells of Patients with Breast Cancer Brain Metastases and Impact on Brain Disease Control.
Cancers (Basel)
June 2022
HER2 expression switching in circulating tumor cells (CTC) in breast cancer is dynamic and may have prognostic and predictive clinical implications. In this study, we evaluated the association between the expression of HER2 in the CTC of patients with breast cancer brain metastases (BCBM) and brain disease control. An exploratory analysis of a prospective assessment of CTC before (CTC1) and after (CTC2) stereotactic radiotherapy/radiosurgery (SRT) for BCBM in 39 women was performed.
View Article and Find Full Text PDFArticle Synopsis
- Chagas disease (ChD) can cause serious heart issues, and ICDs are commonly used to prevent sudden cardiac death in affected patients; however, the effectiveness of MTWA testing in this context hasn't been explored before.
- A study followed 72 patients with ICDs, finding that 81.8% of ChD patients had non-negative MTWA results, and those results were linked to a higher risk of death or necessary ICD interventions.
- The research suggests that MTWA testing could help identify ChD patients at high risk for complications, potentially guiding the need for additional treatments like antiarrhythmic drugs.