Integrated approach for estimating climate change impacts on CO sink capacity of inland waterbodies using hydrodynamic modelling and GIS analysis.

As one of their key regulatory ecosystem functions, inland lakes serve as CO sinks. The CO sink capacity of inland lakes depends on their water temperature and salinity as well as their water volume which are all highly sensitive to climate conditions. This paper aims to quantitatively estimate the change in the CO sink capacity of Wadi El-Rayan Lakes under climate change scenarios.

Anti-hepatocellular carcinoma activities of novel hydrazone derivatives downregulation of interleukin-6.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related morbidity worldwide. Sorafenib is a first-line drug for the treatment of HCC, however, it is reported to cause serious adverse effects and may lead to resistance in many patients. In this study, 20 hydrazone derivatives incorporating triazoles, pyrazolone, pyrrole, pyrrolidine, imidazoline, quinazoline, and oxadiazine moieties were designed, synthesized, and characterized.

The Preferential Therapeutic Potential of against Aflatoxin-Induced Hepatic Injury in Quail.

Aflatoxins (AFs) are the most detrimental mycotoxin, potentially hazardous to animals and humans. AFs in food threaten the health of consumers and cause liver cancer. Therefore, a safe, efficient, and friendly approach is attributed to the control of aflatoxicosis.

Water quality assessment of Lake Burullus, Egypt, utilizing statistical and GIS modeling as environmental hydrology applications.

GIS is a very powerful tool for analyzing huge amount of data and connecting them with the geography; moreover, recently, there is great advancement in the field. The main objective of this study is to assess the water quality (WQ) and trophic status (TS) conditions of Lake Burullus, Egypt, using statistical modeling (PCA/FA and CA), WQ index (L-WQI), and trophic status index (Carlson TSI and TRIX) approaches, in addition to using GIS tools for building models able to automatically calculate the various indices and producing color coded maps for the lake. The results indicated that PCA/FA grouped the twenty-four WQ parameters into nine principal components explaining 72.

Water quality modeling and management for Rosetta Branch, the Nile River, Egypt.

Rosetta Branch (RB) is the Nile western branch, which is considered the main freshwater resource for the western governorates of the Nile Delta, in addition to El-Beheira governorate, Egypt. This work aims to investigate the effectiveness of applying six feasible water quality management scenarios for the RB at Kafr Elzayat (KZ) City, where two major pollution sources (industrial companies and the Tala Drain) are discharging their effluents to the branch. A hydro-ecological model for the branch was developed based on MIKE 11 modeling system (3 modules).

The Potential Safe Antifibrotic Effect of Stem Cell Conditioned Medium and Nilotinib Combined Therapy by Selective Elimination of Rat Activated HSCs.

Hepatic fibrosis is a progressive disease with serious clinical complications that arise from abnormal propagation and activation of multiple inflammatory pathways. Nilotinib is an oral tyrosine kinase inhibitor with antifibrotic activity. Mesenchymal stem cells (MSCs) are blank cells and can differentiate into specific cell types.

Coronavirus (SARS-CoV-2) in gastroenterology and its current epidemiological situation: An updated review until January 2021.

Coronaviruses are positive-sense single-strand RNA viruses that infect amphibians, birds, and mammals. Coronavirus Disease 2019 (COVID-19) has become a major health problem caused by one of the coronaviruses called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has spread fast throughout the globe since its first identification in Wuhan, China, in December 2019.

Antioxidative Capacity of Liver- and Adipose-Derived Mesenchymal Stem Cell-Conditioned Media and Their Applicability in Treatment of Type 2 Diabetic Rats.

Type 2 diabetes mellitus (T2DM) is mainly characterized by insulin resistance and impaired insulin secretion, which cannot be reversed with existing therapeutic strategies. Using mesenchymal stem cells (MSCs), cell-based therapy has been demonstrated in displaying therapeutic effects in T2DM for their self-renewable, differentiation potential, and immunosuppressive properties and higher levels of angiogenic factors. Stem cell therapies are complicated and have a serious adverse effect including tumor formation and immunogenicity, while using mesenchymal stem cell-conditioned media (MSC-CM) significantly reduces stem cell risk, maintaining efficacy and showing significantly higher levels of growth factors, cytokines, and angiogenic factors that stimulate angiogenesis and promote fracture healing in diabetes.

Surface water quality management for drinking use in El-Beheira Governorate, Egypt.

This research was initiated to assess and manage water quality status of fourteen surface drinking water intakes in El-Beheira Governorate, Egypt. The study was conducted on four main branches of water resources in the governorate. Three water quality indices (WQIs) and two multivariate statistical techniques were applied, based on the Egyptian guidelines for the Nile River.

Water quality monitoring of Lake Burullus (Egypt) using Landsat satellite imageries.

Lake Burullus is one of the most important coastal lakes in Egypt, as it participates with a considerable amount of fish yield in Egypt. Despite its importance, it is considered as a vulnerable lake, since it is subjected to significant environmental changes caused by various anthropogenic activities. Severe deterioration of its water quality status, as well as a decrease in its water area, has been noticed throughout the last four decades.

Current coronavirus (SARS-CoV-2) epidemiological, diagnostic and therapeutic approaches: An updated review until June 2020.

Coronaviruses are a group of enveloped viruses with non-segmented, single-stranded, and positive-sense RNA genomes. In December 2019, an outbreak of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in Wuhan City, China. The World Health Organization (WHO) declared the coronavirus outbreak as a global pandemic in March 2020.

Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats.

Mercury is a global environmental pollutant, accumulating mainly in the kidney and liver inducing hepatorenal toxicity, oxidative stress, and tissue damage. Oxidative stress is caused by an imbalance between free radicals' production and cellular antioxidant defense systems. In the present study, we investigated the effect of N N'-diphenyl-1, 4-phenylenediamine (DPPD) antioxidant activity against mercury chloride- (HgCl-) induced renal and hepatic toxicity.

Zinc Oxide Nanoparticle Synergizes Sorafenib Anticancer Efficacy with Minimizing Its Cytotoxicity.

Cancer, as a group, represents the most important cause of death worldwide. Unfortunately, the available therapeutic approaches of cancer including surgery, chemotherapy, radiotherapy, and immunotherapy are unsatisfactory and represent a great challenge as many patients have cancer recurrence and severe side effects. Methotrexate (MTX) is a well-established (antineoplastic or cytotoxic) chemotherapy and immunosuppressant drug used to treat different types of cancer, but its usage requires high doses causing severe side effects.

Assessment of climate change impacts on water quality parameters of Lake Burullus, Egypt.

Egyptian Mediterranean coast hosts five shallow lagoons which play a vital role in the national economy. Lake Burullus is the second largest one that is located in the Nile Delta and is connected to the Mediterranean by a narrow outlet. This lagoon faces various anthropogenic-induced implications that threat its ecosystem and biodiversity.

Change detection for Lake Burullus, Egypt using remote sensing and GIS approaches.

Lake Burullus is the second largest natural coastal lake in Egypt. It has an economic importance for fish yield. However, several anthropogenic activities such as industrial, agriculture, and reclamation activities lead to a deterioration of its water quality and a decrease of the water body area of the lake.

HCC-DETECT: a combination of nuclear, cytoplasmic, and oncofetal proteins as biomarkers for hepatocellular carcinoma.

Currently, the search for suitable hepatocellular carcinoma (HCC) biomarkers is very intensive. Besides, efficacy and cost/effectiveness of screening and surveillance of cirrhotics for the diagnosis of HCC is still debated. So, the present study is concerned with the evaluation of cytokeratin-1 (CK-1) and nuclear matrix protein-52 (NMP-52) for identifying HCC.

Eco-friendly finishing agent for cotton fabrics to improve flame retardant and antibacterial properties.

This research work deals with flame retardant and antibacterial finishing agent for cellulosic fabrics using TiO2 nanoparticles and chitosan phosphate. TiO2 nanoparticles were prepared by sol-gel method using titanium tetraisopropoxide. The size of TiO2 nanoparticles was characterized using transmission electron microscope (TEM).