Publications by authors named "Elsayed Z Soliman"
To broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals for sinus node dysfunction (SND), distal conduction disease (DCD) and pacemaker (PM) implantation. We identified 13, 31 and 21 common variant loci for SND, DCD and PM, respectively.
View Article and Find Full Text PDFBackground -Smoking is associated with arrhythmia and sudden cardiac death, but the biological mechanisms remain unclear. In electrocardiogram (ECG) recordings abnormal durations of ventricular repolarization (QT interval), atrial depolarization (P wave), and atrioventricular depolarization (PR interval and segment), predict cardiac arrhythmia and mortality. Previous analyses of the National Health and Nutrition Examination Survey (NHANES) database for associations between smoking and ECG abnormalities were incomplete.
View Article and Find Full Text PDFAim: Create an ECG-based model to predict dementia and compare its performance with the existing Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) model.
Methods And Results: Participants without prevalent dementia in the Atherosclerosis Risk in Communities study were studied. Visit 4 (V4) (1996-98, mean age, 62 years) and V5 (2011-13, mean age, 75 years) were used as baselines.
The association of alcohol intake with incident atrial fibrillation (AF) remains controversial, particularly among older adults. This study explores the association of alcohol intake with incident AF in older adults in the Atherosclerosis Risk in Communities (ARIC) cohort. Data were obtained from ARIC, a community-based cohort aimed to identify risk factors for cardiovascular disease.
View Article and Find Full Text PDFPersons with long-standing, poorly controlled diabetes or recent hyperglycemia had the highest burden of cardiac autonomic neuropathy. Cardiac autonomic neuropathy contributed to elevated long-term incidence of cardiovascular disease and mortality even in persons with well-controlled diabetes.
View Article and Find Full Text PDFIntroduction: Both low family income and subclinical myocardial injury (SCMI) are risk factors for cardiovascular disease (CVD) mortality. However, the impact of their joint association on CVD mortality is unclear.
Methods: This analysis from the third National Health and Nutrition Examination Survey included 6805 participants (age 59.
Article Synopsis
- Silent myocardial infarction (SMI) often goes unnoticed but increases cardiovascular risks, and it's unclear how intensive lowering of systolic blood pressure (SBP) affects SMI risk in hypertensive patients.
- In a post hoc analysis of the Systolic Blood Pressure Intervention Trial (SPRINT), participants who underwent intensive SBP lowering (targeting <120 mmHg) had a lower incidence of SMI compared to those with standard SBP targets (<140 mmHg).
- The study concluded that intensive SBP lowering not only reduces the risk of recognized myocardial infarction (RMI) but also has significant benefits in preventing SMI in adults with hypertension.
Aims: Despite the highest prevalence of stroke, obesity, and diabetes across races/ethnicities, paradoxically, Hispanic/Latino populations have the lowest prevalence of atrial fibrillation and major Minnesota code-defined ECG abnormalities. We aimed to use Latent Profile Analysis in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) population to obtain insight into epidemiological discrepancies.
Methods And Results: We conducted a cross-sectional analysis of baseline HCHS/SOL visit.
Background: This systematic review aims to determine the impact of isolated diastolic hypertension (IDH) on cardiovascular outcomes.
Methods: We searched only English language articles on PubMed and SCOPUS until July 31, 2023 to investigate the association between IDH and cardiovascular outcomes.
Results: This meta-analysis of 19 studies evaluated the impact of different hypertension diagnostic guidelines (ACC/AHA: American Heart Association/American College of Cardiology; JNC7: Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; NICE/ESC: National Institute for Health and Care Excellence/European Society of Cardiology) on hypertension-related outcomes.
Background: ARCADIA compared apixaban to aspirin for secondary stroke prevention in patients with cryptogenic stroke and atrial cardiopathy. One possible explanation for the neutral result is that biomarkers used did not optimally identify atrial cardiopathy. We examined the relationship between biomarker levels and subsequent detection of AF, the hallmark of atrial cardiopathy.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the relationship between serum calcium levels and ventricular repolarization time, specifically the QT and JT intervals, which are important for heart health.
- Researchers conducted large-scale genome-wide analyses to explore potential interactions between calcium levels and genetic variants associated with QT and JT intervals, using over 122,000 participants.
- The results showed limited evidence for the hypothesized calcium interaction effects, suggesting that other factors, such as rare genetic variations or environmental influences, likely play a larger role in the unexplained heritability of QT and JT intervals.
Subclinical myocardial injury (SCMI) is associated with an increased risk of poor cardiovascular disease (CVD) outcomes. Understanding the underlying risk factors for SCMI is crucial for the prevention and management of CVD. We hypothesized that atherogenic dyslipidemia, a combination of high triglycerides (TG) and low high-density lipoprotein cholesterol (HDL-C), is associated with an increased risk of SCMI.
View Article and Find Full Text PDFBackground: The relationship between self-rated health (SRH) and cardiovascular events in individuals with hypertension, but without diabetes mellitus, is understudied.
Methods: We performed a post hoc analysis of data from SPRINT (Systolic Blood Pressure Intervention Trial). SRH was categorized into excellent, very good, good and fair/poor.
Background: The association of malignant left ventricular hypertrophy (LVH), a specific subphenotype of LVH characterized by elevated levels of high-sensitivity cardiac troponin (hs-cTnT) or N-terminal pro-B-type natriuretic peptide (NT-proBNP), with cognitive decline remains understudied.
Methods: This post-hoc analysis included a total of 8,027 (67.9 ± 9.
Article Synopsis
- * The study analyzed data from 1,590 older adults using long-term ECG monitors (Zio XT Patch) to assess PA and HRV over 14 days while measuring cognitive function.
- * Results indicated that higher PA correlates with better overall cognitive function and lower risks of mild cognitive impairment and dementia, while HRV showed no significant connection to cognitive outcomes.
Cardiac mechanics and the risk of atrial fibrillation in a community-based cohort of older adults.
Eur Heart J Cardiovasc Imaging
November 2024
Article Synopsis
- The study aimed to compare standard and new cardiac measures to better predict atrial fibrillation (AF) risk in older adults who have not previously experienced AF or stroke.
- A total of 5,050 participants, average age 75, were analyzed over seven years, finding that specific measures related to the left atrium (LA) significantly enhanced AF risk prediction compared to previous methods like the CHARGE-AF score.
- Results indicated that LA function metrics, such as reservoir strain and contraction strain, were particularly effective in improving prediction accuracy, suggesting their importance in assessing AF risk among older adults.
Background: Hs-cTnT (cardiac troponin T measured with a highly sensitive assay) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) may identify adults with hypertension who derive greater cognitive benefits from lower systolic blood pressure targets.
Methods: In the SPRINT (Systolic Blood Pressure Intervention Trial) MIND study, participants were categorized as having both hs-cTnT and NT-proBNP in the lower 2 tertiles (n=4226), one in the highest tertile (n=2379), and both in the highest tertile (n=1506). We assessed the effect of intensive versus standard treatment on the composite of mild cognitive impairment (MCI) or probable dementia (PD) across biomarker categories.
Background: High blood pressure (BP) induces left atrial structural and functional remodeling that increases susceptibility to atrial arrhythmia. We hypothesized that lower systolic BP (SBP) levels are associated with a lower prevalence of premature atrial contractions (PACs) in patients with hypertension.
Methods: This analysis included 4,697 participants (mean age 62±13.
Association of Cumulative Systolic Blood Pressure With Left Atrial Function in the Setting of Normal Left Atrial Size: The Atherosclerosis Risk in Communities (ARIC) Study.
J Am Soc Echocardiogr
September 2024
Article Synopsis
- Lower left atrial (LA) function is linked to higher risk of cardiovascular issues, and this study explores how cumulative systolic blood pressure (cSBP) impacts LA strain in older adults with normal LA size.
- The research included 3,859 participants with data collected from 1987 to 2013, finding that each 10 mm Hg increase in cSBP correlates with a slight reduction in LA function, although these effects diminish when considering left ventricular (LV) health.
- The study concludes that while higher cumulative blood pressure is associated with lower LA strain, especially in those with normal LV function, the primary impact seems to stem from blood pressure's influence on heart muscle function.
The impact of oral anticoagulants (OACs) on cognitive impairment and dementia in patients with atrial fibrillation (AF) is not well characterized. This systematic review aims to address this knowledge gap. SCOPUS and PubMed searches were conducted to identify articles in the English language investigating the association between the use of OACs and cognitive impairment and dementia.
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- Deep terminal negative of the P wave in V1 (DTNPV1) serves as a marker for left atrial remodeling and is associated with an increased risk of ischemic stroke.
- In a study involving over 10,600 participants, DTNPV1 was linked to a 1.50-fold higher likelihood of stroke even after accounting for other risk factors and treatments.
- While DTNPV1 improved risk classification for those not developing stroke, it did not significantly enhance stroke prediction when combined with existing risk scoring models.
: Although the link between lead exposure and patterns of cardiovascular disease (CVD) has been reported, its association with silent myocardial infarction (SMI) remains unexplored. We aimed to assess the association between blood lead levels (BLLs) and SMI risk. : We included 7283 (mean age 56.
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- This study investigates the relationship between physical activity (PA) and heart rate variability (HRV) with cognitive function in older adults using long-term ECG monitors and accelerometers.
- The research involved 1,590 participants aged 72-94, showing that higher PA was linked to better cognitive scores and significantly lower risks of mild cognitive impairment (MCI) and dementia, while HRV did not show a significant correlation.
- Findings suggest promoting physical activity may help improve cognitive function and reduce the likelihood of dementia in aging populations, highlighting the importance of monitoring PA through wearable technology.
Article Synopsis
- - The study investigated the prevalence of frequent premature ventricular contractions (PVCs) and nonsustained ventricular tachycardia (NSVT) in community-based women who are likely to have electrocardiogram (ECG) screening, focusing on postmenopausal participants at high risk for atrial fibrillation (AF).
- - Among 1,067 women screened, 4.3% had frequent PVCs and 1.1% had episodes of NSVT, with both conditions showing a correlation to higher risk scores for having AF.
- - Findings suggest that frequent PVCs are relatively common in this group, indicating that ongoing AF screening strategies should consider the prevalence of these incidental ventricular arrhythmias for better clinical decision