Vitamin D3 mitigates aspirin-induced gastric injury by modulating gastrokines, E-cadherin, and inhibiting NLRP3 and NF-κB/MMP-9 signaling pathway.

Background: The prevalence of gastric ulcers has grown significantly in the modern era affecting 10 % of global population. Aspirin downregulates gastrokines 1(GKN1) expression in gastric mucosa and GKN1 down-regulation results in gastric cancer. Vitamin D3 (Vit.

Optimization and characterization studies of poultry waste valorization for peptone production using a newly Egyptian Bacillus subtilis strain.

Valorization of poultry waste is a significant challenge addressed in this study, which aimed to produce cost-effective and sustainable peptones from poultry waste. The isolation process yielded the highly potent proteolytic B.subtilis isolate P6, identified through 16S rRNA gene sequencing to share 94% similarity with the B.

Data solidarity: Operationalising public value through a digital tool.

Most data governance frameworks are designed to protect the individuals from whom data originates. However, the impacts of digital practices extend to a broader population and are embedded in significant power asymmetries within and across nations. Further, inequities in digital societies impact everyone, not just those directly involved.

Evaluation of minced beef quality fortified with edible microalgae species during cryogenic storage.

The aim of this study is to evaluate the effect of some microalgae species adding with different forms on minced beef meat shelf life during cryogenic storage for 13 days. Chlorella vulgaris and Arthrospira platensis are chosen because of their safety and high nutritional value. Microalgae nanoparticles with their different forms have been prepared by using emulsification solvent evaporation method.

The Prevalence and Diagnostic Patterns of Oral and Maxillofacial Lesions: A Seven-Year, Retrospective, Single-Center Cone Beam Computed Tomography and Histopathology Study in Saudi Arabia.

To determine the prevalence of oral and maxillofacial lesions among patients at King Abdulaziz University from January 2016 to December 2022. : This cross-sectional observational study included patients diagnosed with oral and maxillofacial intra-bony lesions based on radiological findings and confirmed by histopathological examination. The lesions were classified according to the fourth edition of the World Health Organization Classification of Head and Neck Tumors.

Anti-mutated citrullinated vimentin antibodies as a biomarker for interstitial lung disease in patients with rheumatoid arthritis.

Objectives: We aimed to assess the anti-mutated citrullinated vimentin (anti-MCV) antibodies in RA patients' serum and to explore their association with interstitial lung disease (ILD).

Methods: Eighty rheumatoid arthritis (RA) patients and forty healthy controls were included in this case-control study. Of these patients, forty had ILD, and forty without ILD.

Role of violence exposure on altruistic behavior and grit among emergency nurses in rural hospitals.

Aim: To explore the effect of violence exposure on altruistic behavior and grit among emergency nurses in 103-bed emergency departments in rural hospitals in Egypt.

Background: Workplace violence is a pervasive issue in emergency departments. Nurses in rural hospitals, facing limited resources and isolation, may be even more vulnerable to the adverse effects of workplace violence.

Complications of electrosurgery: mechanisms and prevention strategies.

Background: Electrosurgery is widely used in all surgical specialities. There is evidence that surgeons in different disciplines and with different experience levels have an inadequate understanding of the basics of electrosurgery and its complications. This can increase the risk of electrosurgical complications.

Deep regression analysis for enhanced thermal control in photovoltaic energy systems.

Efficient cooling systems are critical for maximizing the electrical efficiency of Photovoltaic (PV) solar panels. However, conventional temperature probes often fail to capture the spatial variability in thermal patterns across panels, impeding accurate assessment of cooling system performance. Existing methods for quantifying cooling efficiency lack precision, hindering the optimization of PV system maintenance and renewable energy output.

A systematic review and meta-analysis of interventions to delabel low-risk penicillin allergies with consideration for sex and gender.

Aims: Sex and gender may influence penicillin allergy label (PAL) prevalence and outcomes. This review evaluates the effectiveness and safety of direct delabelling (DD) and oral challenge (OC) for low-risk patients and examines sex and gender differences in reporting and outcomes.

Methods: We searched PubMed, Database of Abstracts of Reviews and Effects, ClinicalTrials.

A combined therapy of meropenem-ZnO nanoparticles efficiently eliminates carbapenem-resistant Klebsiella pneumoniae biofilms, with reduced nephrotoxicity (in vitro).

In response to the World Health Organization's research agenda of antimicrobial resistance in human health, this study appraised the antibacterial and antibiofilm synergistic activity of meropenem and ZnO nanoparticles (ZnO-NPs) combination against carbapenem-resistant Klebsiella pneumoniae (CRKP). The minimum inhibitory concentration (MIC) of meropenem in combination was found to be ~1/12 of its MIC alone. The results of microtiter dilution assay showed that the combination was more efficient in reducing the biofilm biomass than meropenem alone or ZnO-NPs alone.

Emergency Nurses' Knowledge, Perceptions, and Practices Toward Alarm Fatigue and the Obstacles to Alarm Management: A Path Analysis.

Introduction: Frequent and long-term exposure to clinical alarms can cause emergency nurses to lose their trust in alarms, delay their response, and even disable or mute these alarms.

Methods: A cross-sectional study was conducted to assess emergency nurses' knowledge, perceptions, and practices toward clinical alarm fatigue and investigate the perceived obstacles they face when managing clinical alarms.

Results: Less than half of emergency nurses were unfamiliar with the term "alarm fatigue" (40.

Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress.

Objectives: Hepatotoxicity is a severe outcome of methotrexate (MTX) therapy, limiting its clinical use and contributing to its related morbidity and mortality. This study investigated the hepatoprotective effects of nitazoxanide (NTZ), an antiprotozoal drug, against MTX-induced hepatotoxicity and whether endoplasmic reticulum (ER) stress-modulation underlies the expected beneficial effects of NTZ.

Methods: Thirty-six rats were allocated to six groups, one control group and five MTX groups, where induction of hepatotoxicity was achieved via injecting MTX (20 mg/kg).

A comparative study on the effect of melatonin and orlistat combination versus orlistat alone on high fat diet-induced hepatic changes in the adult male albino rats (a histological and morphometric study).

Background: Nonalcoholic fatty liver disease (NAFLD) is the extremely usual reason of chronic liver disease, extending from simple hepatic steatosis (HS), nonalcoholic steatohepatitis (NASH) to advanced hepatic fibrosis and cirrhosis. Though orlistat is a Food and Drug Administration (FDA) approved drug for long-duration management of obesity, few cases of severe hepatic insult were declared. Melatonin is an efficient antioxidant; it also regulates metabolic processes that lead to fat accumulation and obesity.

Single-visit endodontic treatment under general anaesthesia in adult and adolescent patients with special needs: a systematic review.

To improve dental care for individuals with special needs, it is crucial to understand the effectiveness of endodontic treatments under general anaesthesia. This systematic review explores the feasibility, prognostic factors, and outcomes of root canal treatment and pulpotomy performed under general anaesthesia in adult and adolescent patients with special needs. A comprehensive search of Cochrane Library and MEDLINE databases was conducted until July 2024.

Biologically active metabolites of diversity, statistical optimization, and future perspectives.

is a Gram-negative, rod-shaped bacterium that is common in the environment and has been reported to have various bioactive metabolites of industrial potential applications, including antifungal, antibacterial, antimycobacterial, antiparasitic, anticancer, antioxidant activities. In this review, we highlighted and discussed the respective metabolites, pointing out their chemical diversities, purification, current challenges, and future directions. has an industrial role in biodegradation, biosurfactants, and different enzyme production.

Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections.

Background: Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain.

Methods: In a multicenter, noninferiority trial, we randomly assigned hospitalized patients (including patients in the intensive care unit [ICU]) who had bloodstream infection to receive antibiotic treatment for 7 days or 14 days.

Berberine-loaded iron oxide nanoparticles alleviate cuprizone-induced astrocytic reactivity in a rat model of multiple sclerosis.

Berberine (BBN) is a naturally occurring alkaloid as a secondary metabolite in many plants and exhibits several benefits including neuroprotective activities. However, data on the neuromodulating potential of nanoformulated BBN are still lacking. In the present study, BBN loaded within iron oxide nanoparticles (BBN-IONP) were prepared and characterized by transmission electron microscopy FTIR, X-ray photoelectron spectroscopy particle-size distribution, zeta potential, and HPLC.

A practitioner-centered policy roadmap for ethical computational social science in Germany, Austria, and Switzerland.

Computational Social Science (CSS) utilizes large digital datasets and computational methods to study human behavior, raising ethical concerns about data privacy, informed consent, and potential misuse. This study employs a constructivist grounded theory approach, analyzing 15 in-depth interviews with CSS practitioners in Germany, Austria, and Switzerland. These countries share a European legal context regarding data privacy and hereby provide a comparable regulatory environment for examining ethical considerations.

A supervised machine learning model to select a cost-effective directional drilling tool.

With the increased directional drilling activities in the oil and gas industry, combined with the digital revolution amongst all industry aspects, the need became high to optimize all planning and operational drilling activities. One important step in planning a directional well is to select a directional tool that can deliver the well in a cost-effective manner. Rotary steerable systems (RSS) and positive displacement mud motors (PDM) are the two widely used tools, each with distinct advantages: RSS excels in hole cleaning, sticking avoidance and hole quality in general, while PDM offers versatility and lower operating costs.