leaves, HPLC profile, isolation, and cytotoxicity.

Phytochemicals have played a significant role in the discovery of many clinically anticancer medicines. being famous as an ornamental plant, widely cultivated, and including a wide variety of secondary metabolites this motivated us to explore more about its potential medical applications. In this study, the total methanol extract of leaves (family Apocyanaceae) was sequentially fractionated into hexane, methylene chloride, ethyl acetate, and butanol fractions.

Comparative Anticancer Potentials of Taxifolin and Quercetin Methylated Derivatives against HCT-116 Cell Lines: Effects of -Methylation on Taxifolin and Quercetin as Preliminary Natural Leads.

Six flavonoids present in , i.e., 7,3'-di--methyltaxifolin (), 3'--methyltaxifolin (), 7--methyltaxifolin (), taxifolin (), 3--methylquercetin (), and quercetin (), were tested for their anticancer activities.

Proposed Mechanism for Emodin as Agent for Methicillin Resistant Staphylococcus Aureus: In Vitro Testing and In Silico Study.

In the search for a new anti-MRSA lead compound, emodin was identified as a good lead against methicillin-resistant (MRSA). Emodin serves as a new scaffold to design novel and effective anti-MRSA agents. Because rational drug discovery is limited by the knowledge of the drug target, α-hemolysin of was used in this study because it has an essential role in infections and because emodin shares structural features with compounds that target this enzyme.

Litoarbolide A: an undescribed sesquiterpenoid from the Red Sea soft coral with an anti-malarial activity evaluation.

Soft corals distributed across the Red Sea coasts are a rich source of diverse and bioactive natural products. Chemical probing of the Red Sea soft coral led to isolation and structural characterization of an undescribed sesquiterpenoid, litoarbolide (), along with 14 previously reported metabolites (). The chemical structures of the isolates were assigned based on NMR as well as high resolution electrospray ionization mass spectrometry (HR-ESI-MS) data.

Phytochemical Characterization, In Vitro Anti-Inflammatory, Anti-Diabetic, and Cytotoxic Activities of the Edible Aromatic Plant; .

is a medicinal herb that alleviates inflammations and fever. Chromatographic separation, phytochemical characterization, and in vitro biological activities of the plant -hexane extract were conducted for the first time in this study. Six compounds were isolated for the first time from the -hexane fraction of aerial parts and were identified on the bases of NMR and MS analyses as pseudo-taraxaterol (), pseudo-taraxasterol acetate (), 3β-acetoxytaraxaster-20-en-30-aldehyde (), calenduladiol-3--palmitate (), stigmasterol (), and α-tocospiro B ().

Sarcoroseolides A-D, four undescribed cembranoids from the Red Sea soft coral .

Four undescribed cembranoids, sarcoroseolides () along with nine reported related cembranoids () were isolated from the soft coral . The chemical structures of sarcoroseolides - were elucidated by extensive 1 D and 2 D NMR as well as HR-ESIMS spectroscopic data. Moreover, the geometric and absolute configurations were assigned by the modified Mosher's method and/or NOESY experiments.