Publications by authors named "Elsa Mauricio Reus"
Article Synopsis
- This study examines how canagliflozin, an SGLT2 inhibitor, impacts heart function and potentially improves cardiovascular outcomes for heart failure patients through effects on redox signaling.!
- Researchers conducted multiple studies, involving patient biopsies and cell cultures, to see how this drug influences oxidative stress and inflammation in heart tissue, finding that it reduces harmful enzyme activity while enhancing protective mechanisms.!
- The results suggest that canagliflozin operates through SGLT1/AMPK/Rac1 signaling, leading to reduced inflammation and cell death in heart muscle cells, uncovering a new mechanism behind its positive cardiac effects.!
Background: Although dementia is associated with non-participation in cognitive and social activities, this association might merely reflect the consequences of dementia, rather than any direct effect of non-participation on the subsequent incidence of dementia. Because of the slowness with which dementia can develop, unbiased assessment of any such direct effects must relate non-participation in such activities to dementia detection rates many years later. Prospective studies with long-term follow-up can help achieve this by analysing separately the first and second decade of follow-up.
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