Publications by authors named "Elsa Chen"
Article Synopsis
- The study focuses on overcoming the challenge of eradicating the viral reservoir to find a clinical cure for HIV-1 by using a combination of N-803 and broadly neutralizing antibodies (bNAbs) in rhesus macaques that were previously treated with antiretroviral therapy (ART).
- Researchers found that while the treatment induced some immune activation and transient viral levels, it did not significantly lower the viral reservoir. However, about 70% of treated macaques achieved sustained control of the virus after stopping ART.
- The success of viral control was linked to changes in CD8 T cells induced by the combination treatment, suggesting that eliminating the viral reservoir may not be necessary for long-term remission
Zika virus infection in humans has been associated with serious reproductive and neurological complications. At present, no protective antiviral drug treatment is available. Here, we describe the testing and evaluation of the antiviral drug, galidesivir, against Zika virus infection in rhesus macaques.
View Article and Find Full Text PDFThe precise time when the viral reservoir is seeded during acute HIV-1 infection remains unclear. We previously demonstrated that the viral reservoir was seeded by day 3 following SIVmac251 infection in rhesus monkeys. Here we report the impact of initiating ART on day 0 (6 h), 1, 2, or 3 following intrarectal SIVmac251 infection in 20 rhesus monkeys (N = 5/group).
View Article and Find Full Text PDFIn this Brief Communications Arising Comment, the first three authors (Osuna, Lim and Kublin) should have been listed as equally contributing authors; this has been corrected online.
View Article and Find Full Text PDFWe report the complete genome sequence of Klebsiella oxytoca E718, a New Delhi metallo-β-lactamase-1 (NDM-1)-producing strain isolated from a renal transplant patient. The genome contains a 6,097,032-bp chromosome and two multidrug resistance plasmids with sizes of 324,906 bp and 110,781 bp.
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