Intracranial subdural hematoma after lumbar myelography.

Two cases of intracranial subdural hematoma after lumbar myelography are reported. This complication should be considered in patients who complain of prolonged headache or who develop neurological signs after lumbar puncture.

Dementia and hydrocephalus in Paget's disease: a case report.

Dementia and hydrocephalus in an elderly female were related to basilar impression caused by Paget's disease of the skull. Ventricular and lumbar thecal pressures were normal, but isotope cisternography suggested obstructive hydrocephalus. The patient improved after ventricular shunting.

Observations on brain abscess. Review of 28 cases.

Twenty-eight cases of intracranial abscess managed at the Alfred Hospital, Melbourne, over ten years are reviewed. In half the cases, a brain abscess was a complication of paracranial infection. In one-third of the cases, infection arose from distant spread, usually from the heart.

Control of concanavalin A receptor mobility by cytoplasmic actin in human tumour cells.

Tissue culture monolayers of seven human intracranial tumours comprising 2 astrocytomas, 3 meningiomas, 1 secondary squamous cell carcinoma and 1 secondary adenocarcinoma were examined by a double immunofluorescent staining technique to demonstrate Concanavalin A (Con A) surface receptors and cytoplasmic actin in the same cell. Tumour cells, treated with fluoresceinisothiocyanate-labelled Con A (FITC-Con A) showed staining in cell margins or in a random distribution over the cell surface. Incubating the cells with FITC-Con A at 37 degrees for increasing periods of time resulted first in staining of clusters and later of perinuclear globules.

Increased expression of actin-like protein in human and ethylnitrosourea-induced tumors of the nervous system.

Twenty-one human intracranial tumors comprising 15 astrocytomas and 6 meningiomas and 26 ethylnitrosourea-induced rat neural tumors comprising 7 astrocytomas and 9 schwannomas were examined by indirect immunofluorescence for reactivity with a human anti-actin antibody. In cryostat sections both human and rat astrocytomas showed an increased reaction with the anti-actin antibody compared to normal astrocytes, and the reaction with astrocytomas was greater than that with meningiomas. Malignant rat schwannomas also showed prominent anti-actin staining contrasting with the negative reaction in normal Schwann cells.

Smooth muscle associated antigen in astrocytes and astrocytomata.

Four human and 4 rat astrocytomata and mammalian adult brain and spinal cord were examined by indirect immunofluorescence with human serum containing smooth muscle antibody. Cryostat sections of astrocytomata showed staining of the tumour cell cytoplasm and processes while in normal adult brain and spinal cord the entire astrocyte stained. Impression film and tissue culture monolayers of astrocytomata showed staining of cell processes and a fine, filamentous network in the cell body.