Unlabelled: Treatment of recurrent oropharyngeal candidiasis (OPC) in HIV-infected patients is a serious clinical problem due to the emergence of resistant Candida strains, the risk of invasive disease, and high economic costs, which warrants the need for new treatment regimens.
Aim: To improve the treatment regimen of OPC in the later stages of HIV infection by combining the complex herbal medicinal product Tonsilgon N with fluconazole and evaluate the effectiveness of this combination.
Materials And Methods: A comparative randomized clinical study included 65 patients divided into observation and comparison groups, receiving fluconazole plus Tonsilgon H and fluconazole monotherapy, respectively, for 7 days.
Candida lesion of Palatine tonsils was studied in 32 HIV-infected patients in the late stages of the disease using histological and cytological methods. There were used conventional methods during pathomorphological studies of palatine tonsils tissue fragments obtained by biopsy, and smears from the surface of the organ. It was found that micromycetes spp.
View Article and Find Full Text PDFVestn Otorinolaringol
March 2018
The surgical intervention for the management of frontal sinusitis is required in a large fraction of patients presenting with this condition. The treatment of choice for the pathology in question is endoscopic endonasal frontotomy. Whenever the endoscopic technique is impossible to employ, the surgeon has to resort to an extranasal operation on the frontal sinus.
View Article and Find Full Text PDFOropharyngeal candidiasis in 512 HIV-infected patients at the late stages of the disease was studied with special reference to the clinical and microbiological characteristics of this condition. The diagnosis was established based on the results of the clinical and microbiological examination of the patients including investigation of the tissue samples taken from the oral cavity and the throat with the use of the device specially developed for this purpose. It was shown that the disease existed in various clinical forms the most common of which were monocomponent pathology represented by pseudomembranous candidiasis in 37.
View Article and Find Full Text PDFVestn Otorinolaringol
March 2018
The present article was designed to describe the history of the Department of Otorhinolaryngology based at the Academician E.A. Vagner Perm State Medical University and overview its research, educational, and therapeutic activities.
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February 2015
The objective of the present biomechanical and clinical study was to evaluate the consequences of the preservation of stapedius muscle tendon during stapedoplasty. The biomechanical investigations included mathematical simulation with the construction of the model based on the kinematic approach. The comparative clinical study of the results of stapedoplasty carried out between 2001 and 2010 involved 340 patients (77 men and 263 women) at the mean age of 48.
View Article and Find Full Text PDFThe objective of the present study was to elucidate, in the framework of a biomechanical model, the biomechanical prerequisites for the development of osteodystrophic changes in stirrup bones in the case of their osteodystrophic fixation. The comparative analysis of the biomechanical models of mobile and ankylotic stapes demonstrated that the mild enough strain-stress state under the normal conditions turns into the rigid state in otosclerosis. The main dampher in case of load application to the adequately mobile stapes footplates is the round ligament.
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