Publications by authors named "Eloise Durame"
Article Synopsis
- - Collective cell migration is important for processes like development, healing, and cancer spread, and in the study of Drosophila, border cells (BCs) migrate with the help of a kinase called Misshapen (Msn).
- - The protein Tao serves as an important activator of Msn in border cells; reducing Tao levels hinders BC migration, mimicking the effects of a loss of Msn function.
- - Msn's distribution is influenced by its interaction with a protein called Rap2l, which assists in transporting Msn to the endolysosomal pathway for degradation; this process is critical for maintaining balanced Msn levels and activity in BCs.
Cell motility is a critical feature of invasive tumour cells that is governed by complex signal transduction events. Particularly, the underlying mechanisms that bridge extracellular stimuli to the molecular machinery driving motility remain partially understood. Here, we show that the scaffold protein CNK2 promotes cancer cell migration by coupling the pro-metastatic receptor tyrosine kinase AXL to downstream activation of ARF6 GTPase.
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