Publications by authors named "Eloi Mili"
Article Synopsis
- Myofibroblasts in atherosclerotic plaques play a vital role in disease progression by producing extracellular matrix and contributing to the structure of plaques, yet smooth muscle cells are often used for research instead.
- The study introduces a new method to isolate and culture plaque myofibroblasts from 27 donors, which maintain their growth and retain characteristics of their original cellular environment.
- This research confirms that cultured myofibroblasts closely resemble those found in plaques and can be used effectively in studies examining various mechanisms of atherosclerosis.
Article Synopsis
- * The study utilized RNA sequencing data to create gene regulatory networks, revealing two main SMC phenotypes in women: a vulnerable myofibroblast-like network and a contractile network, which differed in expression levels compared to males.
- * Findings suggest that female atherosclerosis involves specific gene networks that promote plaque vulnerability, with important implications for understanding disease progression and potential treatment strategies.
Women presenting with coronary artery disease (CAD) more often present with fibrous atherosclerotic plaques, which are currently understudied. Phenotypically modulated smooth muscle cells (SMCs) contribute to atherosclerosis in women. How these phenotypically modulated SMCs shape female versus male plaques is unknown.
View Article and Find Full Text PDF