Publications by authors named "Elodie Hedou"

Article Synopsis
  • Tissue-type plasminogen activator (tPA) has different effects on the nervous system depending on its form, specifically the two-chains form (tc-tPA) activates the MET receptor.
  • This activation leads to a cascade that recruits NMDA receptors (NMDARs) and promotes the degradation of GluN2B subunit-containing NMDARs, effectively reducing their signaling.
  • The study reveals how tc-tPA influences neuronal survival by mediating interactions between MET and GluN2B-NMDARs, suggesting a new mechanism of action for tPA in the nervous system.
View Article and Find Full Text PDF

Cerebral ischemia is a pathology involving a cascade of cellular mechanisms, leading to the deregulation of proteostasis, including macroautophagy/autophagy, and finally to neuronal death. If it is now accepted that cerebral ischemia induces autophagy, the effect of thrombolysis/energy recovery on proteostasis remains unknown. Here, we investigated the effect of thrombolysis by PLAT/tPA (plasminogen activator, tissue) on autophagy and neuronal death.

View Article and Find Full Text PDF

Cerebral ischemia is a complex pathology involving a cascade of cellular mechanisms, which deregulate proteostasis and lead to neuronal death. Proteostasis refers to the equilibrium between protein synthesis, folding, transport, and protein degradation. Within the brain proteostasis plays key roles in learning and memory by controlling protein synthesis and degradation.

View Article and Find Full Text PDF