Ibrutinib treatment affects collagen and von Willebrand factor-dependent platelet functions.

The oral Bruton's tyrosine kinase inhibitor, ibrutinib, has recently demonstrated high efficiency in patients with relapsed B-cell malignancies. Occurrence of bleeding events has been reported in a subgroup of ibrutinib-treated patients. We demonstrate that ibrutinib selectively inhibits platelet signaling and functions downstream of the collagen receptor glycoprotein VI and strongly affects firm platelet adhesion on von Willebrand factor (VWF) under arterial flow.

Perceptual-motor constraints on decision making: the case of the manual search behavior for hidden objects in toddlers.

In the C-not-B task, 2.5-year-old children tend to look for an object in a location to which the hiding agent moved his hand (C) after moving an object from A to B. In three experiments, the authors investigated the nature of the constraints underlying toddlers' performance in this task.

Benefits of napping and an extended duration of recovery sleep on alertness and immune cells after acute sleep restriction.

Understanding the interactions between sleep and the immune system may offer insight into why short sleep duration has been linked to negative health outcomes. We, therefore, investigated the effects of napping and extended recovery sleep after sleep restriction on the immune and inflammatory systems and sleepiness. After a baseline night, healthy young men slept for a 2-h night followed by either a standard 8-h recovery night (n=12), a 30-min nap (at 1 p.

Undetected changes in visible stimuli influence subsequent decisions.

Change blindness-our inability to detect changes in a stimulus-occurs even when the change takes place gradually, without any disruption [Simons, D. J., Franconeri, S.